The primary DNA lesion induced by malondialdehyde, a byproduct of lipid peroxidation and prostaglandin synthesis, is 3-(2'-deoxy-beta-D-erythro-pentofuranosyl)-pyrimido[1, 2-a]purin-10(3H)-one (M1G). When placed opposite cytosine (underlined) at neutral pH in either the d(GGTMTCCG).d(CGGACACC) or d(ATCGCMCGGCATG). d(CATGCCGCGCGAT) duplexes, M1G spontaneously and quantitatively converts to the r...

We present a simple and efficient approach to ring-inring nanostructures from readily available starting materials through self-assembly process. The self-assembly tool kit includes divalent dipyridyl ligands, Pd(II) metal ions, and β-cyclodextrin (β-CD). A series of dipyridyl ligands are shown to form inclusion complexes with β-CD in aqueous solution as a result of hydrophobic interactions. On...

Pupylation is a bacterial post-translational modification of target proteins on lysine residues with prokaryotic ubiquitin-like protein Pup. Pup-tagged substrates are recognized by a proteasome-interacting ATPase termed Mpa in Mycobacterium tuberculosis. Mpa unfolds pupylated substrates and threads them into the proteasome core particle for degradation. Interestingly, Mpa itself is also a pupyl...

4-(Alkylamino)carbonyl-1-(alkoxy)carbonyl-2-azetidinones (9-11) have been prepared in five steps from 4-(benzyloxy)carbonyl-1-(t-butyldimethyl)silyl-2-azetidinone (1). The beta-lactam reactivity of 9 has been established by 1H NMR experiment. Compound 11 was a good reversible inhibitor of PPE and HLE. Based on theoretical design, series of 2-azetidinones (12-17) and 4-(alkoxy)carbonyl-2-azetidi...

In this position paper we discuss a set of problems particular to computing within limits that draws on psychological and sociological barriers. The enormity of the predicaments we are facing, global climate change and resource scarcity, together with the social, cultural and national settings in which we are facing these predicaments, are seriously hampering our possibility to address them. We...

A skew Laurent polynomial ring S = R[x;α] is reversible if it has a reversing automorphism, that is, an automorphism θ of period 2 that transposes x and x and restricts to an automorphism γ of R with γ = γ. We study invariants for reversing automorphisms and apply our methods to determine the rings of invariants of reversing automorphisms of the two most familiar examples of simple skew Laurent...

OBJECTIVE To estimate 24-month continuation rates of all reversible contraceptive methods for women enrolled in the Contraceptive CHOICE Project. METHODS We analyzed 24-month data from the 9,256 participants enrolled in the Contraceptive CHOICE Project, a prospective observational cohort study that provides no-cost contraception to women in the St. Louis region. The project promoted the use o...

The oxidation of [n]nickelocenophanes [Ni(?5-C5H4)2(CH2)3] (3), [Ni(?5-C5H4)2(SiMe2)2] (10), [Ni(?5-C5H4)2(SiMe2)2O] (11), [Ni(?5-C5H4)2(CH2)4] (12), and poly(nickelocenylpropylene) [Ni(?5-C5H4)2(CH2)3]n (4) to both the monocationic dicationic species was investigated in dichloromethane by cyclic voltammetry (CV) square-wave voltammetry. presence acetonitrile on potentials 3 also CV. 10–12 exhi...

BACKGROUND NuvaRing is a combined contraceptive vaginal ring designed for 3 weeks continuous use followed by a 1 week ring-free period. The present study evaluated ovarian function in women who were instructed to either adhere to, or deviate from, the recommended regimen of use. METHODS In this open-label, randomized study, 45 women aged between 18 and 35 years used NuvaRing for one cycle in ...

Light-driven transcription, replication and enzyme catalysis are critically dependent upon a delicate transfer between molecular and supramolecular chirality. Chemists have well realized the impressive stereospecificity over many thermally accessible cycloaddition with chiral catalysts, but making light work in the enantiomer control of diarylethene photocyclization has proved to be more challe...