Regenerative failure remains a significant barrier for functional recovery after central nervous system (CNS) injury. As such, understanding the physiological processes that regulate axon regeneration is a central focus of regenerative medicine. Studying the gene transcription responses to axon injury of regeneration competent neurons, such as those of the peripheral nervous system (PNS), has p...

Experimental and Clinical Research Center, an institutional cooperation between the Charité Medical Faculty and the Max-Delbruck Center for Molecular Medicine, Berlin, Germany; Max-Delbruck Center for Molecular Medicine, Berlin, Germany; Faculty of Medicine, Dresden University of Technology, Dresden, Germany; Department of Neurology, University of Erlangen, Erlangen, Germany; Stem Cells and Imm...

Won Sun Park,* Soon Chul Heo,* Eun Su Jeon, Da Hye Hong, Youn Kyoung Son, Jae-Hong Ko, Hyoung Kyu Kim, Sun Young Lee, Jae Ho Kim,* and Jin Han* Department of Physiology, Kangwon National University School of Medicine, Chuncheon, Korea; Medical Research Center for Ischemic Tissue Regeneration, Medical Research Institute, Department of Physiology, School of Medicine, Pusan National University, Ya...

Since the monumental publication in 1998 by Pittenger et al., mesenchymal stem cells (MSCs) have been a center player of regenerative medicine and now a number of clinical trials using MSCs have been conducted in various fields of tissue regeneration including those of bone. It cannot be denied that due to enthusiastic clinical demanding, clinical application of MSCs has launched with little kn...

The size and shape of tissues are tightly controlled by synchronized processes among cells and tissues to produce an integrated organ. The Hippo signaling pathway controls both cell proliferation and apoptosis by dual signal-transduction states regulated through a repressive kinase cascade. Yap1 and Tead, transcriptional regulators that act downstream of the Hippo signaling kinase cascade, have...

Osteoarthritis (OA) is a degenerative joint disease caused by variety of factors, which highly prevalent in the elderly population and mainly characterized articular cartilage degeneration surrounding bone regeneration, with clinical manifestations repeated swelling, pain, stiffness deformity at later stage. OA chronic that gives patients their relatives many life inconveniences economic pressu...

Department of Biomedical Imaging and Image-guided Therapy, Christian Doppler Laboratory for Cardiac and Thoracic Diagnosis and Regeneration, Department of Dermatology, Head FFG Project 852748 “APOSEC”, Department of Thoracic Surgery, Medical University Vienna, Vienna, Austria Correspondence to: Hendrik Jan Ankersmit, MD, MBA. Department of Thoracic Surgery, Medical University of Vienna, Vienna,...

The ability to biologically manipulate musculoskeletal healing and augment bone and soft tissue repair and regeneration holds great promise. Advances in the basic science study and clinical application of bioactive proteins and growth factors continues to evolve. Improvement in the surgical resurfacing of articular cartilage defects and tendon and ligament repair through the addition of bioacti...

Disease, trauma, and aging account for a significant number of clinical disorders. Regenerative medicine is emerging as a very promising therapeutic option. The design and development of new cell-customized biomaterials able to mimic ECM functionalities represent one of the major strategy to control the cell fate and stimulate tissue regeneration. Recently, hydrogels have received a considerabl...