Glaucoma diagnosis involves extracting three features of the fundus image; optic cup, optic disc and vernacular. Present manual diagnosis is expensive, tedious and time consuming. A number of researches have been conducted to automate this process. However, the variability between the diagnostic capability of an automated system and ophthalmologist has yet to be established. This paper discusse...

This paper presents systematic methods for the detection of influential individuals that affect the log odds (LOD) score curve. We derive general formulas of influence functions for profile likelihoods and introduce them into two standard quantitative trait locus detection methods-the interval mapping method and single marker analysis. Besides influence analysis on specific LOD scores, we also ...

How to measure the performance of an edge detection method is an open problem. Many performance measures have been presented in the literature. However, there seems to be no agreement on the best option, and there exist no practical studies of the features of some of the most recent measures. In this work we make a comprehensive overview of the different proposals, followed by a practical compa...

Liu, Jing Ph.D., Purdue University, May 2015. Quantitative mRNA Detection with Advanced Nonlinear Microscopy. Major Professor: Joseph M.K. Irudayaraj. Cell-specific information on quantity and localization of key mRNA transcripts in single-cell level are critical to the assessment of cancer risk, therapy efficacy, and effective prevention strategies. While current techniques are not capable to ...

Change detection is a technology ascertaining the changes of specific features within a certain time interval. It provides the spatial distribution of features and qualitative and quantitative information of features changes. The quantitative analysis and identifying the characteristics and processes of surface changes is carried through from the different periods of remote sensing data. There ...

Developing portable and low-cost methods for quantitative detection of large protein biomarkers and small molecular toxins can play a significant role in controlling and preventing diseases or toxins outbreaks. Despite years of research, most current methods still require laboratory-based or customized devices that are not widely available to the general public for quantitative analysis. We hav...

DNA detection is commonly used in molecular biology, pathogen analysis, genetic disorder diagnosis, and forensic tests. While traditional methods for DNA detection such as polymerase chain reaction (PCR) and DNA microarrays have been well developed, they require sophisticated equipment and operations, and thus it is still challenging to develop a portable and quantitative DNA detection method f...

BACKGROUND: Aflatoxin B1 (AFB1) is a toxic metaboliteproduced by Aspergillus species that contaminates a wide range ofagricultural products. OBJECTIVES: This study was designed todevelop a rapid and highly sensitive immunoassay method inmicroarray format for quantitative detection of AFB1 to evaluatethe potential of microarray platform for high-throughput screening,which can be beneficial in fo...

The aim of this study was to develop an event-specific qualitative and real-time quantitative polymerase chain reaction (PCR) method for detection of herbicide-tolerance genetically modified (GM) soybean A2704-12. The event-specific PCR primers were designed, based on the 5'-flanking integration sequence in the soybean genome, to amplify the 239-bp target fragment. Employing the same event-spec...

pet (positron emission tomography) is a powerful imaging technique that can provide quantitative information on the distribution of positron emitter labeled radiopharmaceuticals (pet radiopharmaceuticals) in the body. positrons (ß+) are positively charged beta particles. they are emitted when the atom is proton rich. a positron has only a transient existence. after losing all of its kinetic ene...