BACKGROUND AND PURPOSE In this study, intensive video electroencephalogram (EEG) monitoring, high-resolution MR imaging (MR imaging), proton MR spectroscopy ((1)H-MR spectroscopy) and single-photon emission CT (SPECT) were compared in patients with temporal lobe epilepsy (TLE) to evaluate lateralization of affected hemisphere with regard to bilateral affection and postoperative outcome. PATIE...

PURPOSE To determine the neurometabolism of patients with active neuropsychiatric systemic lupus erythematosus (NPSLE) by using proton MR spectroscopy. METHODS Thirty-six patients with SLE and eight control subjects were studied with proton MR spectroscopy to measure brain metabolites. Peaks from N-acetylaspartate (NAA), creatine (Cr), choline (Cho), and at 1.3 parts per million (ppm) lipid, ...

BACKGROUND AND PURPOSE MR spectroscopy allows the noninvasive evaluation of in vivo brain metabolites. Our purpose was to use this technique to assess metabolic alterations in the human cerebrum during growth, maturation, and aging. METHODS Ninety normal human brains in subjects aged 4 to 88 years were examined with multivoxel proton MR spectroscopy. Spectra were obtained from specific voxels...

Gülin Öz, PhD Jeffry R. Alger, MPhil, PhD Peter B. Barker, MPhil Robert Bartha, PhD Alberto Bizzi, MD Chris Boesch, MD, PhD Patrick J. Bolan, PhD Kevin M. Brindle, DPhil, Cristina Cudalbu, PhD Alp Dinçer, MD Ulrike Dydak, PhD Uzay E. Emir, PhD Jens Frahm, PhD Ramón Gilberto González, MD, PhD Stephan Gruber, PhD Rolf Gruetter, PhD Rakesh K. Gupta, MD Arend Heerschap, PhD Anke Henning, PhD Hoby P...

BACKGROUND AND PURPOSE Proton MR spectroscopy has recently been applied to the evaluation of seizures, but few comparisons have been made between different clinical spectroscopic techniques. Our goal was to determine whether there is a significant difference between hippocampal NAA/(Cho+Cr) ratios obtained by single-voxel spectroscopy (SVS) and by chemical-shift imaging (CSI). METHODS Twelve ...

We report magnetic resonance (MR) imaging findings including diffusion-weighted imaging and proton MR spectroscopy findings in a patient with infantile Refsum disease. The initial diagnosis was made on the basis of history, clinical findings and biochemical studies. Bilateral and symmetrical involvement of the peritrigonal white matter, centrum semiovale, thalami, corpus callosum and corticospi...

BACKGROUND Epilepsy, a well-known mostly idiopathic neurologic disorder, has to be correctly diagnosed and properly treated. Up to now, several diagnostic approaches have been processed to determine the epileptic focus. OBJECTIVES The aim of this study was to discover whether proton-MR-spectroscopic imaging (MRSI) aids in the diagnosis of temporal lobe epilepsy in conjunction with classical e...

PURPOSE Children who have brain tumors are at risk for a variety of treatment-related sequelae, including neuropsychological and cognitive impairment, neurologic deficits, and neuroendocrinologic disturbances. We sought to determine the value of proton MR spectroscopy in assessing brain tissue remote from the tumor site to ascertain the effects of chemotherapy and radiation treatment in these p...

PURPOSE To measure the accuracy of single-voxel, image-guided proton MR spectroscopy in distinguishing normal from abnormal brain tissue and neoplastic from nonneoplastic brain disease. METHODS MR spectroscopy was performed at 0.5 T with the point-resolved spectroscopic pulse sequence and conventional postprocessing techniques. Subjects consisted of a consecutive series of patients with suspe...

BACKGROUND AND PURPOSE The clinical relevance of proton MR spectroscopy needs further clarification as to its usefulness and limitations. The purpose of this study was to investigate the correlation between the semiquantitative choline-containing compound level (Cho value) measured by MR spectroscopy and the Ki-67 labeling index in gliomas. METHODS Localized proton spectra were obtained in 26...