BACKGROUND First-episode psychosis is typically preceded by a prodrome in which there is deterioration in global and social functioning. AIMS To examine whether the duration of the prodromal phase influences grey and white matter volumes at the onset of psychosis. METHODS Eighty-two people were scanned using magnetic resonance imaging when they developed a first episode of psychosis. The du...

Persons who are at risk for Huntington's Disease (HD) can be tested for the HD gene expansion before symptom onset. People with the gene expansion, but no clinical diagnosis, are in the prodromal phase of HD. This study explored quality of life (QOL) in prodromal HD. Interviews about QOL, conducted with 9 prodromal HD participants and 6 companions, were transcribed. Discourse was coded for emot...

This article presents the rationale, design, and preliminary findings of the North American Prodrome Longitudinal Study (NAPLS), a collaborative, multisite investigation into the earliest phase of psychotic illness. We describe how 8 independently conceived research projects were integrated methodologically, how diagnostic reliability was achieved across sites on the Structured Interview for Pr...

Citation: Liu J, Ciarochi J, Calhoun VD, Paulsen JS, Bockholt HJ, Johnson HJ, Long JD, Lin D, Espinoza FA, Misiura MB, Caprihan A, Turner JA and PREDICT-HD Investigators and Coordinators of the Huntington Study Group (2018) Genetics Modulate Gray Matter Variation Beyond Disease Burden in Prodromal Huntington’s Disease. Front. Neurol. 9:190. doi: 10.3389/fneur.2018.00190 genetics Modulate gray M...

congenital anomalies of coronary arteries, albeit rare, may be significant contributors to angina pectoris, hemodynamic abnormalities, and sudden cardiac death. a 47-year-old man referred to us with atypical chest pain. electrocardiography demonstrated no significant ischemic changes, but cardiac troponin i test was positive. the patient underwent coronary angiography, which revealed a single c...

discussion hydatid cyst in pericardium represents only 0.5-2% of cases of systemic echinoccocal infection. isolated pericardial cyst is very rare in endemic region and may present mimicking acute coronary syndrome. cardiac hydatid cysts should always be considered in presence of eosinophilia as present like acute coronary syndrome in endemic area. introduction hydatid cysts are most commonly fo...

most of the patients imagine that chest pain is not sign of heart attack. but, may be pain is not sign of heart attack. pain source may be from pulmonary, stomach, intestinal, psychologic or musculoskeletal problems. from these factors, when two or more factors combine to each other, similar signs are happen. all of these factors harden diagnosis of chest pain reason. only with separation of pe...

background: significant elevation of cardiac biomarkers after percutaneous coronary intervention (pci) is associated with increased mortality. however, clinical importance of lesser degrees of cardiac enzyme elevation has not been well understood. multiple factors might have an etiologic role, and the incidence of myonecrosis has not changed dramatically despite pharmacological and technologica...

acute myocardial infarction (mi) during pregnancy is rare and mi due to prinzmetal's angina is much rarer. we present a 35-year-old, obese, multigravida, and pre-eclamptic woman, who developed acute anterior wall mi at the 30th week of gestation. on coronary angiography, the second obtuse marginal branch was totally occluded and the right coronary artery (rca) was normal. three days later, she ...

unstable angina has progressive process and even in rest time, it happens frequently. it is a serious situation and 15-20 percent of patients are dying in duration of one year. treatment: patients often hospitalized because observation of their reactions to treatment is easier in hospital. treatment plan must be explain for them carefully. when patient’s situation due to anxiety is critical, be...