Lung, prostate, and stomach cancer are the most prevalent cancers among males. Breast, colon, cervical women. The literature also shows that patients suffering from increasing constantly, hence number of different chemotherapy treatments administered is increasing. main objective this review article to summarize effect age on half-life some antineoplastic drugs belonging category Topoisomerase ...

background: malignant neoplasms remain the second leading cause of death in children after accidents. the aim of this study was to assess the epidemiology of childhood cancer in children admitted to dr sheikh hospital, iran. materials and methods: this descriptive cross- sectional study had been done in dr sheikh hospital in mashhad university of medical science on 1764 children younger than 14...

Human papillomavirus (HPV)16 is the most oncogenic human papillomavirus, responsible for most papillomavirus-induced anogenital cancers. We have explored by sequencing and phylogenetic analysis the viral variant lineages present in 692 HPV16-monoinfected invasive anogenital cancers from Europe, Asia, and Central/South America. We have assessed the contribution of geography and anatomy to the di...

Although cancer incidence and mortality rates in the United States and some European countries have started to decrease, those in developing countries are increasing. China, the most populous developing country, is facing a serious challenge from cancer. Cancer incidence has been increasing for decades, and cancer is the leading cause of death in China. In 2012, the cancer incidence was 174.0 p...

normal 0 false false false en-us x-none ar-sa background: cadmium and lead compounds are classified as human carcinogens by several regulatory agencies. twenty five percent of all cancer-related deaths are attributed to gastrointestinal cancers (gi ca). we investigated the levels of 2 different heavy metals (cd and pb) in the soils of the lenjanat region, isfahan province, central iran where in...

background: an explosion of research has been done in discovering how human health is affected by environmental factors. i will discuss the impacts of environmental cancer causing factors and how they continue to cause multiple disruptions in cellular networking. some risk factors may not cause cancer. other factors initiate consecutive genetic mutations that would eventually alter the normal p...

background: carcinoma of the fallopian tube is extremely uncommon neoplasm, accounting for only 0.3% of gynecologic cancers. case: a 17-year-old female patient presented with clinical symptoms of right side deep pelvic pain. ultrasound examination reveals right adenxal mass with breakdown suggesting neoplastic lesion or tubo-ovarian abscess. she was diagnosed clinically as tubo-ovarian mass for...

mTOR has been implicated in survival signals for many human cancers. Rapamycin and TGF-β synergistically induce G1 cell-cycle arrest in several cell lines with intact TGF-β signaling pathway, which protects cells from the apoptotic effects of rapamycin during S-phase of the cell cycle. Thus, rapamycin is cytostatic in the presence of serum/TGF-β and cytotoxic in the absence of serum. However, i...