About 10 years have elapsed since the first whole-genome scanning studies in the mouse to identify loci that affect susceptibility or resistance to tumorigenesis. In that time, >100 cancer modifiers have been mapped, and four strong candidate genes have been identified. Cancer modifier loci affect almost all types of mouse tumorigenesis, with some loci acting on the entire tumorigenic process, ...

Real-Time Optimization (RTO) via modifier adaptation is a class of methods for which measurements are used to iteratively adapt the model via input-affine additive terms. The modifier terms correspond to the deviations between the measured and predicted constraints on the one hand, and the measured and predicted cost and constraint gradients on the other. If the iterative scheme converges, thes...

PURPOSE The purpose of the present study was to evaluate the flexural strength of the joint between glass-infiltrated alumina frames and the experimental adjusting agent (MA modifier) that contains alumina and magnesia. METHODS A commercially available adjusting agent (Optimizer), a slurry of alumina powder (Alumina modifier), and a bulk specimen (joint-free alumina) were used as controls. Be...