The technologies employed for the preparation of conventional tissue engineering scaffolds restrict the materials choice and the extent to which the architecture can be designed. Here we show the versatility of stereolithography with respect to materials and freedom of design. Porous scaffolds are designed with computer software and built with either a poly(D,L-lactide)-based resin or a poly(D,...

In this study, polylactide/urea complexes were successfully prepared by the electrospinning method, then the host urea component was removed to obtain a coalesced poly(L-lactide) (PLLA)/poly(D-lactide) (PDLA) blend. The crystallization behavior of the coalesced PLLA/PDLA blend (c-PLLA/PDLA) was studied by a differential scanning calorimeter (DSC) and Fourier transform infrared (FTIR) spectrosco...

Coronary bioresorbable vascular scaffolds are a new appealing therapeutic option in interventional cardiology. The most used and studied is currently the Absorb BVS™. Its backbone is made of poly-L-lactide and coated by a thin layer of poly-D,L-lactide, it releases everolimus and is fully degraded to H2O and CO2 in 2-3 years. Absorb BVS™ seems to offer several theoretical advantages over metall...

The research work reported in this paper is extension of our previous findings related to intercalation of procainamide hydrochloride, an antiarrythmia drug in interlayer gallery of Na(+)-clay (montmorillonite). The microcomposite particles prepared from procainamide-montmorillonite hybrid and poly L-lactide were characterised by scanning electron microscope and atomic force microscopy analysis...

Mechanically tough poly(L-lactide) (PLLA)/ N,N -dimethylacetamide (DMAc) gels by rapid quenching using liquid nitrogen (LN) were synthesized. PLLA/DMAc solution at 110 °C was cooled room temperature (PLLA-RT), or quenched LN before keeping RT (PLLA-LN). PLLA-RT with the PLLA concentrations of 5, 8, and 11 wt% did not form gel, while 14 17 could brittle gel exhibiting coarse structures. In contr...

Biodegradable polylactide microparticles with encapsulated cytotoxic protein viscumin were obtained via the ultrasound-assisted supercritical fluid technique. The size of the microparticles was 10-50 µM, as shown by electron microscopy. The time course of viscumin release from microparticles was studied using an immunoenzyme test system with anti-viscumin monoclonal antibodies. It was found tha...

Polymerization of racemic lactide initiated by divalent ytterbium complexes supported by either dimethylamino-amino bis(phenolate) or methoxy-amino bis(phenolate) ligands proceeds rapidly at room temperature in a living fashion to give heterotactic polylactide with the racemic enchainment of monomer units P(r) ranging from 0.97-0.99.