Poly(lactic acid) (PLA) and starch copolymers are obtained by reactive blending varying the starch compositions from 0 to 60%. PLA is functionalized with maleic anhydride (MA), obtaining PLA-g-MA copolymers using dicumyl peroxide as an initiator of grafting in order to improve the compatibility and interfacial adhesion between the constituents. PLAþ starch blends without a compatibilizer do not...

This study aimed to optimize the preparation conditions of pachyman (PHY)-loaded poly(d,l-lactic acid) (PLA) (PHYP) nanospheres by response surface methodology, explore their characteristics, and assess their effects on splenic lymphocytes. Double emulsion solvent evaporation was used to synthesize PHYP nanospheres, and the optimal preparation conditions were identified as a concentration of po...

Objective(s): Electrospun nanofibrous mats of poly(lactic acid) (PLA) and nanohydroxyapatite (nano-HA) were prepared and proliferation and differentiation of mesenchymal stem cells on the prepared nanofibers were investigated in this study. Materials and Methods: PLA/nano-HA nanofibers were prepared by electrospinning. The effects of process parameters, such as nano-HA concentration, distance, ...

Low cytotoxicity and high gene transfection efficiency are critical issues in designing current non-viral gene delivery vectors. The purpose of the present work was to synthesize the novel biodegradable poly (lactic acid)-poly(ethylene glycol)-poly(l-lysine) (PLA-PEG-PLL) copolymer, and explore its applicability and feasibility as a non-viral vector for gene transport. PLA-PEG-PLL was obtained ...

peripheral nerve injuries caused by traffic accidents, resections of tumors or iatrogenic side effects of the surgeries are few of the most common form of trauma occurring with up to 500,000 cases each year in iran. conventional strategies including nerve coaptation, and the application of autografts, allografts and xenografts are restricted due to the limited availability of donors, immune-rej...

Antimicrobial films of poly (lactic acid) (PLA)/D-limonene/zinc oxide (ZnO)-based bio-nanocomposites were prepared via melt compounding and subsequent thermocompression. D-limonene was incorporated at concentrations 10 or 20 wt%, ZnO pure nanoparticles those organically modified with oleic acid (O-ZnO), an average diameter 13.5 nm, included 3, 5, 8 wt%. The plasticizing effect D-Limonene corrob...

The potential of neat poly(lactic acid) (PLA) and PLA/cellulose nanocrystal (CNC) blown films in extending the shelf-life crackers, a moisture-sensitive food product, was assessed. Product’s shelf-life, i.e., time required by crackers to reach its critical moisture content (CMC) 8%, determined experimentally from versus storage plots at constant temperature (25 °C) various conditions relative h...

We examine different approaches for the controlled release of L-lactate, which is a signaling molecule that participates in tissue remodeling and regeneration, such as cardiac muscle tissue. Robust, flexible, self-supported 3-layers films made two spin-coated poly(lactic acid) (PLA) layers separated by an electropolymerized poly(3,4-ethylenedioxythiophene) (PEDOT) layer, are used loading delive...

Abstract In this work, the effect of two different types bioactive coatings on properties 3D printed poly(lactic acid)/montmorillonite (PLA/MMT) nanocomposite scaffolds was examined. To improve their suitability for bone tissue engineering applications, PLA were coated with (i) ordered mesoporous Strontium bioglass (SrBG) and (ii) SrBG nanohydroxyapatite (nHA) using a simple dip coating procedu...