نتایج جستجو برای: poloxamer 127
تعداد نتایج: 15382 فیلتر نتایج به سال:
Current treatment protocols for postoperative pain are beset by either the short duration of the anesthetic effect or requirement of hospitalization of the patients. We reported herein a novel treatment by applying to the surgical site a biodegradable microparticle-gel system for prolonged and localized release of encapsulated anesthetic drugs. In a previous publication, lidocaine-loaded poly(D...
A combination of fusion and surface adsorption techniques was used to enhance the dissolution rate of cefuroxime axetil. Solid dispersions of cefuroxime axetil were prepared by two methods, namely fusion method using poloxamer 188 alone and combination of poloxamer 188 and Neusilin US2 by fusion and surface adsorption method. Solid dispersions were evaluated for solubility, phase solubility, fl...
Conventional ophthalmic solutions often eliminate rapidly after administration and can’t provide and maintain an adequate concentration of drug in the precorneal area. This can be overcome by the use of in situ gel forming systems that are instilled as drops into the eye and undergo a sol-gel transition in the culde-sac. The present work describes the formulation and evaluation of an ophthalmic...
Nanoparticles (NPs) have long gained significant interest for their use in various drug formulations in order to increase bioavailability, prolong drug release, and decrease side effects of highly toxic drugs. The objective of this investigation was to evaluate the potential of ethyl cellulose-based NPs (EC-NPs) to modulate the release and reduce ulcerogenicity of piroxicam (PX) after oral admi...
Gonzalez EA, Hunter R, Kozar RA, Moore FA. Poloxamer 188-Hypertonic saline provides optimal ileal protection after mesenteric ischemia/reperfusion. J Surg Res 2007;137;337 Gonzalez EA, Hunter R, Kozar RA, Weisbrodt N, Field E, Moore FA.Poloxamer 188 resuscitation after mesenteric ischemia/reperfusion abrogates neutrophil mediated ileal mucosal injury. Journal of Trauma 2006;61:514.
BACKGROUND The aim of this study was to investigate the intestinal mucus-penetrating properties and intestinal cellular uptake of two types of liposomes modified by Pluronic F127 (PF127). METHODS The two types of liposomes, ie, PF127-inlaid liposomes and PF127-adsorbed liposomes, were prepared by a thin-film hydration method followed by extrusion, in which coumarin 6 was loaded as a fluoresce...
Oxaliplatin (OXP) was reported to show low anti-tumor activity when used alone and to display side effects; this low activity was attributed to high partitioning to erythrocytes and low accumulation in tumors. Thermosensitive liposomes (TSL) were considered able to specifically deliver drugs to heated tumors and to resolve the OXP distribution problem. Regretfully, TSL encapsulating doxorubicin...
BACKGROUND Nanoparticles fabricated from the biodegradable and biocompatible polymer, polylactic-co-glycolic acid (PLGA), are the most intensively investigated polymers for drug delivery systems. The objective of this study was to explore fully the development of a PLGA nanoparticle drug delivery system for alternative preparation of a commercial formulation. In our nanoparticle fabrication, ou...
BACKGROUND Self-emulsifying drug delivery system is an isotropic mixture of natural or synthetic oils, non-ionic surfactants or, one or more hydrophilic solvent and co-solvents/surfactant and polymer that improve bioavailability and increase solubility of poorly-soluble drugs. OBJECTIVES This study was aimed to prepare and develop a stable formulation for self-emulsifying drug delivery system...
F. Naqvi,1,2,* M. Górska,2 L. Cáceres,2,3,† A. Jungclaus,4 M. Pfützner,5 H. Grawe,2 F. Nowacki,6 K. Sieja,6 S. Pietri,7,‡ E. Werner-Malento,5,§ P. H. Regan,7 D. Rudolf,8 Z. Podolyák,7 J. Jolie,1 K. Andgren,9 T. Beck,2 P. Bednarczyk,2,10 J. Benlliure,11 G. Benzoni,12 A. M. Bruce,13 E. Casarejos,11,‖ B. Cederwall,9 F. C. L. Crespi,12,14 P. Detistov,15,¶ Zs. Dombrádi,16 P. Doornenbal,2,** H. Geiss...
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