PURPOSE Novel spectral-domain optical coherence tomography (SD-OCT) findings in posterior microphthalmos (PM) include cystoid changes in the papillomacular fold (PMF). These changes may be misdiagnosed as cystoid macular edema (CME) and may trigger unnecessary treatment including intravitreal injections. We report a case that underscores this scenario aiming to increase awareness of this entity...

The 2001/2008 World Health Organization (WHO)-based diagnostic criteria for polycythemia vera (PV), essential thrombocythemia (ET) and primary myelofibrosis (PMF) were recently revised to accomodate new information on disease-specific mutations and underscore distinguishing morphologic features. In this context, it seems to be reasonable to compare first major diagnostic criteria of the former ...

Splenomegaly is a major manifestation of primary myelofibrosis (PMF) contributing to clinical symptoms and hematologic abnormalities. The spleen from PMF patients contains increased numbers of hematopoietic stem cells (HSC) and megakaryocytes (MK). These MK express high levels of P-selectin (P-sel) that, by triggering neutrophil emperipolesis, may cause TGF-β release and disease progression. Th...

Jose D. Salas is a professor emeritus of civil and environmental engineering at Colorado State University (CSU). He received BS and civil engineering degrees from the National University of Engineering of Lima, Perú; MSc degree in hydraulics; and PhD degree in hydrology and water resources from CSU. At CSU, he supervised (main advisor) 42 MSc and 37 PhD students. Dr. Salas has been consultant o...

Objectives—Genitourinary tract samples are required to investigate male HIV-1 infectivity. Because semen collection is often impractical, we evaluated the acceptability, feasibility, and validity of post-prostatic massage fluid/urine (post-PMF/U) for studying male genitourinary HIV-1 shedding. Methods—HIV-1-seropositive men were evaluated after 48 hours of sexual abstinence. At each visit, a cl...

Through the simulation of biological Swarm Intelligence generation, a new kind of material flow structure that can be adapted to complex environments, X Party Material Flow (X-PMF), can be established. According to results from the simulation experiments, the PMF, if in the chaord state during the process of autonomy and adaptation, can realize the emergence of Xparty Swarm Intelligence.

In recent years, the area of plastic-mulched farmland (PMF) has undergone rapid growth and raised remarkable environmental problems. Therefore, mapping the PMF plays a crucial role in agricultural production, environmental protection and resource management. However, appropriate data selection criteria are currently lacking. Thus, this study was carried out in two main plastic-mulching practice...

本研究では, 油脂にパーム中融点油脂, 乳化剤にソルビタン脂肪酸エステルを用いて, 放射光マイクロビームX線回折法によって乳化剤結晶のラメラ面の配向と格子間隔が油脂の結晶化に及ぼす影響を調べた. STS添加PMFの回折リングは円弧状または同心円状であり, STSとPMF α 型の結晶のラメラ面の配向はすべての位置においてほぼ同じ向きで結晶化していた一方, STB添加PMFでは, PMF 型の回折リングは濃淡のある円弧およびスポット状のパターンを示し, STB結晶のラメラ面の配向と一致しない位置も認められた. これらの結果から, STS添加PMFではエピタキシャル成長, STB添加PMFでは不均一核形成によってPMF 型が結晶化し, 乳化剤結晶と油脂結晶の格子間隔 (分子の長さ, 副格子構造) の類似度によって, PMFの核形成機構が異なることが示された. また, それらがPMF 型結...

BACKGROUND Primary myelofibrosis (PMF) is an acquired clonal disease of the hematopoietic stem cell compartment, characterized by bone marrow fibrosis, anemia, splenomegaly and extramedullary hematopoiesis. About 60% of patients with PMF harbor a somatic mutation of the JAK2 gene (JAK2-V617F) in their hematopoietic lineage. Recently, a splicing isoform of JAK2, lacking exon 14 (JAK2Δ14) was des...

EZH2 is a component of polycomb repressive complex 2 (PRC2) and functions as an H3K27 methyltransferase. Loss-of-function mutations in EZH2 are associated with poorer outcomes in patients with myeloproliferative neoplasms (MPNs), particularly those with primary myelofibrosis (MF [PMF]). To determine how EZH2 insufficiency is involved in the pathogenesis of PMF, we generated mice compound for an...