نتایج جستجو برای: plc gene

تعداد نتایج: 1146437  

Journal: :The Biochemical journal 1997
A Piiper D Stryjek-Kaminska D Illenberger R Klengel J M Schmidt P Gierschik S Zeuzem

We have recently shown that synthetic peptides of the effector domain of the low-molecular-mass GTP-binding protein Rab3 stimulate inositol 1,4,5-trisphosphate production in various permeabilized cells. To investigate the mechanism of the peptide-induced activation of phospholipase C (PLC) and to identify the PLC isoenzyme(s) targeted by these peptides, isolated pancreatic acinar membranes and ...

1998
Josef Tapken Henning Dierks

Moby/plc is a graphical design tool for PLC-Automata, a special class of hierarchical real-time automata suitable for the description of distributed real-time systems that are implementable on a widely used hardware platform, so-called Programmable Logic Controllers (PLCs). In this paper we sketch the modelling language in use and some features of Moby/plc, like several validation methods and c...

Journal: :Journal of virology 2002
Yvonne K Gruijthuijsen Paola Casarosa Suzanne J F Kaptein Jos L V Broers Rob Leurs Cathrien A Bruggeman Martine J Smit Cornelis Vink

The rat cytomegalovirus (RCMV) R33 gene is conserved among all betaherpesviruses and encodes a protein (pR33) that shows sequence similarity with chemokine-binding G protein-coupled receptors (GPCRs). Previously, the physiological significance of the R33 gene was demonstrated by the finding that an RCMV strain with R33 deleted is severely attenuated in vivo and is unable to either enter or repl...

Journal: :American journal of physiology. Regulatory, integrative and comparative physiology 2014
Quan Jiang Anderson O L Wong

Somatostain (SS) is known to inhibit growth hormone (GH) and prolactin (PRL) secretion. Somatolactin (SL) is a member of the GH/PRL family, but its regulation by goldfish brain somatostatin-28 (gbSS-28) has not been examined. To this end, the structural identity of goldfish SLα was established by 5'/3'-rapid amplification of cDNA ends. As revealed by in situ hybridization and immunohistochemica...

Journal: :Oncology reports 2017
Shuo Cai Ping-Hui Sun Jeyna Resaul Lei Shi Aihua Jiang Lucy K Satherley Eleri L Davies Fiona Ruge Anthony Douglas-Jones Wen G Jiang Lin Ye

Phospholipase C (PLC) regulates a number of cellular behaviours including cell motility, cell transformation, differentiation and cell growth. PLC plays a regulatory role in cancer cells partly by acting as signalling intermediates for cytokines such as EGF and interleukins. The current study examined the expression of the PLC isozymes in human breast cancer and corresponding clinical relevance...

Background: Thoracolumbar spinal fractures include a range of injuries of various severities from simple apophysealfractures to neurological injury and complex fractures associated with vertebral dislocation. The treatment ofthoracolumbar fractures is challenging, especially due to the difficulty of evaluating the posterior ligamentous complex(PLC). The purpose of this study w...

2009
Hyeongtae Park Gi-Nam Wang Sang-Chul Park

Presented in the paper is the PLC symbol naming rules in order to simulate the virtual factory which is operated by the PLC control logic. In the PLC simulation, the corresponding model, normally called as the plant model, to the PLC receives the PLC output signal, operates virtual devices, and sends the changed PLC input signal which is updated by the virtual device movements. Therefore the pl...

Journal: :The Journal of Experimental Medicine 2002
Kentaro Hanada Nirianne Marie Q. Palacpac Pamela A. Magistrado Ken Kurokawa Ganesh Rai Daiji Sakata Tomoko Hara Toshihiro Horii Masahiro Nishijima Toshihide Mitamura

Sphingomyelinase (SMase) is one of the principal enzymes in sphingomyelin (SM) metabolism. Here, we identified a Plasmodium falciparum gene (PfNSM) encoding a 46-kD protein, the amino acid sequence of which is approximately 25% identical to that of bacteria SMases. Biochemical analyses of the recombinant protein GST-PfNSM, a fusion protein of the PfNSM product with glutathione-S-transferase, re...

2016
Xiajie Wen Fengmin Lu Shuang Liu

Several previous studies have investigated the association between gene p53 (p53) mutation and the poor outcome of primary liver cancer (PLC) patients; however, the results remain inconsistent. In the present study, p53 mutation in 60 paired tumor and corresponding nontumor tissues derived from a cohort of 60 PLC patients was systematically analyzed. The results showed that p53 mutation was onl...

Journal: :Plant physiology 1998
J Kopka C Pical J E Gray B Müller-Röber

Many cellular responses to stimulation of cell-surface receptors by extracellular signals are transmitted across the plasma membrane by hydrolysis of phosphatidylinositol-4,5-bisphosphate (PIP2), which is cleaved into diacylglycerol and inositol-1,4,5-trisphosphate by phosphoinositide-specific phospholipase C (PI-PLC). We present structural, biochemical, and RNA expression data for three distin...

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