Serine protease inhibitors (soybean trypsin inhibitor [STI] and Bowman-Birk protease inhibitor [BBI]) found in soybeans have been shown to inhibit melanosome phagocytosis by keratinocytes via protease-activated receptor 2 (PAR-2). Pre-clinical studies have confirmed the skin lightening potential of these molecules. In this study, we investigated the efficacy of a novel soy moisturizer containin...

The natural protective mechanisms of the skin indicate harmful effects sunlight, by appearance erythema and increased sweat secretion. extremely unfavourable influence solar radiation on is phenomenon immunosuppression, which can lead to formation cancer foci. Effective sun protection delays photoaging, prevents sunburn cancer. available sun-protective preparations show increasing photostabilit...

The quest for youth and beauty is an ongoing one. No organ conveys youth and beauty to the extent that skin does. Advances in research over the past several decades have yielded a tremendous amount of information on the molecular pathways involved in both intrinsic aging (natural) and extrinsic aging (photoaging). In this article, we aim to describe the molecular pathways that lead to an aged a...

UV radiation is present in sunlight and can be emitted from numerous artificial sources. Outdoor workers are exposed to sunlight in a wide variety of occupations like sailors, fishers, construction workers, farmers, and other. Presented are the skin diseases caused by sunlight exposure. They may be of little medical importance such as stigmata or create problems like photoaging, skin carcinoma,...

For decades it has been appreciated that aging is the consequence of both genetic and environmental influences. Genetic factors are evident, e.g., in the >100-fold variation among species in the rate of aging; and recent studies of fruit flies, worms, and even mice have identified specific longevity genes whose modification can greatly alter lifespan [22]. Conversely, a role for environmental f...

UVB reduces type I procollagen levels and increases matrix metalloproteinases-1 (MMP-1) levels in human skin and plays a major role in the process of photoaging. We previously reported that fucoidan inhibits UVB-induced MMP-1 expression at the protein and mRNA levels in human skin fibroblasts (HS68). Yet, the effects of fucoidan on UVB-induced MMP-1 promoter activity and type I procollagen have...

Preliminary findings from multiple studies indicate that dietary intake of soy-derived isoflavones exert beneficial effects on the skin including defense against oxidant damage, stimulation collagen synthesis, and increased hydration. This study aims to investigate how oral supplementation a soy protein isolate with added (SPII) affects components photoaging such as facial wrinkles dyspigmentat...