Discovery of novel cocrystal systems and improvement their physicochemical properties dominates the current literature on cocrystals yet required end-product formulation is rarely addressed. Drug product manufacturing includes complex API solid state processing steps such as milling, granulation, tableting. These all require high mechanical stress which can lead to solid-state phase transformat...

Background: Starch of sweet potatoes is one the ingredients that has many benefits, including in pharmaceutical field, especially as a excipient formulations. But it poor flow properties. Objective: The objective study to isolate, characterise, modify and formulate starch Purple (I. batatas L.Poir) into tablet dosage forms. Method: purple potato obtained from isolation, then modified improve it...

Perspectives Children younger than five years old are generally unable to safely swallow solid capsules and tablets larger than 10 mm. 1 Although oral liquid medicines can be prescribed, these have some disadvantages over solid medicines. Substances or excipients that solubilize the active ingredient or ensure microbial stability are included in oral liquids and these may be harmful to young ch...

Both the Valsartan (VAL) and Olmesartan medoxomil (OLM) are widely prescribed anti-hypertensive agents with angiotensin II type I receptor antagonistic activity. VAL OLM of BCS class drugs having a low variable oral bioavailability. Recrystallization from different organic solvents improved its aqueous solubility thereby in vitro dissolution properties. In present investigation, tablets contain...

A very simple, non-destructive, inexpensive and green strategy was applied for the simultaneous determination of ibuprofen (IBP) and paracetamol (PC) using transmission Fourier Transform Infrared (FTIR) spectroscopy in tablet formulations for routine quality control laboratories. For the determination of the active pharmaceutical ingredients (API), KBr pellets containing known amount of standar...

Modern drug distribution systems use single unit packages to a great extent and, in fact, such packages are central to the operation of unit dose systems, intravenous admixture services, and other important aspects of pharmacy practice. These guidelines have been prepared to assist pharmaceutical manufacturers and pharmacists in the development and production of single unit and unit dose packag...

New chromatographic-densitometric assay was developed for identification and determination of risperidone in pharmaceutical formulations. Thin-layer chromatographic plates (TLC-F254) as a stationary phase and n-butanol-acetic acid-water (12:3:5 v/v/v) as a mobile phase were used for separation. Densitometric measurements were done for all constituents at lambda = 280 nm. A decrease in stability...

A simple and sensitive spectrophotometric method was developed and validated for the determination of Theophylline (TH) in pharmaceutical dosage form as well as in human saliva and urine samples. This method is based on the measurement of absorbance of TH in Phosphate Buffer 6.8 at 270 nm. Beer’s law is obeyed over the range of 2-10 μg/ml. This method was used successfully for the quality asses...