BACKGROUND Trigeminal neuralgia (TN) is relatively frequent in multiple sclerosis (MS) patients and can be extremely disabling. Surgical interventions are less effective for the treatment of MS-related TN compared with classic TN, and higher recurrence rates are observed. OBJECTIVE To evaluate initial pain-free response (IPFR), duration of pain-free intervals (PFIs), and factors predictive of...

Abstract. Feature importance has been a popular approach for machine learning models to investigate the relative significance of model predictors. In this study, we developed Wilks feature (WFI) method hydrological inference. Compared with conventional methods such as permutation (PFI) and mean decrease impurity (MDI), proposed WFI aims provide more reliable variable rankings To achieve this, m...

BACKGROUND Chronic inflammation and oxidative stress are key features of chronic obstructive pulmonary disease (COPD). Oxidative stress enhances COPD inflammation under the control of the pro-inflammatory redox-sensitive transcription factor nuclear factor-kappaB (NF-κB). Histone acetylation plays a critical role in chronic inflammation and bromodomain and extra terminal (BET) proteins act as "...

OBJECTIVE The concept of platinum sensitivity and cross-resistance among platinum agents are widely known in the management of recurrent ovarian cancer. The aim of this study was to evaluate two hypotheses regarding the validity of the concept of platinum sensitivity and non-cross-resistance of cisplatin analogue with cisplatin in recurrent cervical cancer. METHODS In this retrospective study...

Globally, sustainable development has been given high priority for the Government agenda in order to achieve a balance of social, economic and environmental factors. The UK government realise the importance and criticality of sustainable development and they intend to use the public procurement power to demand more sustainable public building development to improve energy efficiency and reduce ...

Abstract The prevalence of gastroesophageal reflux disease (GERD) is rapidly increasing due to the adoption a Westernized lifestyle; at same time, safe and efficient treatment required side effects refractoriness proton pump inhibitors (PPIs). frequently used multi-compound for GERD in current traditional Korean medicine (TKM) clinical field comprises Crassostrea gigas Thunberg shell (CGTS), Ba...

BACKGROUND Lenalidomide has dual antiangiogenic and immunomodulatory properties and confirmed antitumor activity in hematologic malignancies. A phase II study investigating the safety and efficacy of continuous lenalidomide in recurrent ovarian cancer patients was initiated. PATIENTS AND METHODS Patients with histologically confirmed epithelial ovarian, fallopian tube or primary peritoneal ca...

BACKGROUND The immune response in patients with melanoma is an important focus of research due to the tumor's resistance and immunotherapy possibilities. IL-27 is one of the cytokines with antitumor properties. The role of IL-27 in the pathogenesis of melanoma is still unclear. The aim of this study was to examine the association between serum IL-27 levels and the clinical parameters of melanom...