Fig. 1. Schematic of one stage bone transport procedure (yellow bone, red periosteum). A portion of diaphyseal bone is denuded of periosteum, osteotomized, and transported over an intramedullary nail to the site of the 2.54-cm critical-sized defect, where it is docked to the distal femur. The periosteal sheath is left in situ to surround the new defect site, leading to full infilling of the new...

Introduction: The quest for finding a regenerative material periodontal defects is everlasting. Numerous resorbable, nonresorbable, synthetic, and autogenous materials have been tried tested in this regard. periosteum has gained popularity field as it exhibited osteogenic properties. harvest of the hassle-free does not cause additional surgical sites. Case Presentation: present case report demo...

Periosteum is known to contain cells that, after isolation and culture-expansion, display properties of mesenchymal stromal/stem cells (MSCs). However, the equivalent cells have not been identified in situ mainly due to the lack of specific markers. Postnatally, stem cells are slow-cycling, long-term nucleoside-label-retaining cells. This study aimed to identify and characterise label-retaining...

The activation step of bone remodeling remains poorly characterized. Activation comprises determination of the site to be remodeled, osteoclast precursor recruitment, their migration to the site of remodeling, and differentiation. These actions involve different compartments and cell types. The aim of this study was to investigate events and cell types involved during activation. We used a bone...

Biodegradable poly([D,L]-lactide-co-glycolide) (PLGA) nanofibrous membrane embedded with two drug-to-polymer weight ratios, namely 1:3 and 1:6, which comprised PLGA 180 mg, lidocaine 20 mg, vancomycin 20 mg, and ceftazidime 20 mg, and PLGA 360 mg, lidocaine 20 mg, vancomycin 20 mg, and ceftazidime 20 mg, respectively, was produced as an artificial periosteum in the treatment of segmental femora...

Osteochondral defects in weight-bearing regions must be repaired with cartilage and subchondral bone support simultaneously, as well as the integration between the 2, particularly in young, active patients. In this study, a new method called mix-mosaicplasty was used to reconstruct large osteochondral defects (6-mm diameter) in the weight-bearing region of the femoral condyle of goats. Two peri...