milk is an important component of a balanced diet and contains many valuable constituents. a considerable part of the milk healthbenefits is related to its proteins, not only for their nutritive value but also for their biological properties. scientific evidence suggests that anticarcinogenic activities, antihypertensive properties, immune system modulation, and other metabolic features of milk...

introduction: bombesin is a 14-aminoacid peptide isolated from frog skin. the mammalian counterparts of the frog peptide are neuromedin b (nmb) and gastrin-releasing peptide (grp). bombesin (bbn) is a peptide showing high affinity for the gastrin releasing peptide receptor (grpr). prostate, small cell lung cancer, breast, gastric, and colon cancers are known to over express receptors to bombesi...

Objective(s): Blocking of vascular endothelial growth factor (VEGF) plays a pivotal role in inhibition of metastasis and is a target for development of anti-angiogenic agents. In this study, a peptide-based vaccine was designed and its potential for induction of humoral immune responses, generation of neutralizing antibodies, inhibition of tumor growth and metastasis w...

objective: animal studies show that vaccination with epitope-based peptides results in protective immunity. however, immunodominance should be regarded as a major challenge in this area. considering the advantages of epitopic-vaccines against hepatitis c virus (hcv) infection, herein, we compared the occurrence of immunodominance following mice immunization with three different hcv epitopic-pep...

Mass spectrometry based glycoproteomics has become a major means of identifying and characterizing previously N-linked glycan attached loci (glycosites). In the bottom-up approach, several factors which include but not limited to sample preparation, mass spectrometry analyses, and protein sequence database searches result in previously N-linked peptide spectrum matches (PSMs) of varying lengths...

Peptide mapping is a component of the analytical toolbox used within the biopharmaceutical industry to aid in the identity confirmation of a protein therapeutic and to monitor degradative events such as oxidation or deamidation. These methods offer the advantage of providing site-specific information regarding post-translational and chemical modifications that may arise during production, proce...

objective: we introduce an rgd (arg-gly-asp)-containing peptide of collagen iv origin that possesses potent cell adhesion and proliferation properties. materials and methods: in this experimental study, the peptide was immobilized on an electrospun nanofibrous polycaprolactone/gelatin (pcl/gel) hybrid scaffold by a chemical bonding approach to improve cell adhesion properties of the scaffold. a...

In todays bioinformatics, Mass spectrometry (MS) is the key technique for the identification of proteins. A prediction of spectrum peak intensities from pre computed molecular features would pave the way to better understanding of spectrometry data and improved spectrum evaluation. We propose a neural network architecture of Local Linear Map (LLM)-type for peptide prototyping and learning local...

Crude protein fractions from Mirabilis jalapa of northern Iran containing Antiviral Protein (MAP) reduced the systemic accumulation a plant RNA virus in Nicotiana benthamiana. A MAP gene was amplified by RT-PCR total RNAs isolated these Iranian M. plants (MAP-Tehran) without 5´-end signal peptide sequence, to set up an experimental system that would transiently express cell cytosol agroinfiltra...