Background Apatinib has shown outstanding value in the treatment of advanced gastric cancer (AGC). However, no biomarkers are available to select AGC patients who will benefit from apatinib. The aim present study was investigate association between p53 and Ki67 expression outcome treated with Methods From December 2015 2020, 92 were enrolled retrospectively evaluated. They given apatinib at a d...

  Objective(s): Regarding the presence of many active biological constituents in Avicennia marina, the present investigation was carried out to study cytotoxic activity of crude methanol leave extract and column chromatographic fractions of A. marina against MDA-MB 231 cell line (human breast cancer cell) and HEK (Human embryonic kidney cell) line .   Materials and Methods: The an...

Background: Characterization of genes and precise assessment of the number of copies are crucial for understanding the basis of emergence, progression, and identification of predictive markers of tumor malignancy. This study aimed to investigate the role of the changes in some central genes in gastric cancer. Materials and Methods: In this experimental study, 30 patients with gastric surgery w...

Background: P53, p63, and p73 transcription factors which are belong to The p53 family, are conserved during evolution. They have important roles in many molecular and cellular functions, including tumor suppression, the development of epithelial cell layers, and the development of central nervous system and immune system. Studies show these molecules also have role in maintaining the genomic i...

Objective(s): The increasing rate of over using cell phones has been considerable in youths and pregnant women. We examined the effect of mobile phones radiation on genes expression variation on cerebellum of BALB/c mice before and after of the birth. Materials and Methods: In this study, amobile phone jammer, which is an instrument to prevent receiving signals between cellular phonesand base t...

Introduction: Staffs of operating room are continuously exposed to anesthetic gases and                                                       ionizing radiation. Adaptive response, as a defense mechanism, will occur when cells become exposed to a low dose of factors harming DNA that causes in the next exposures to higher doses o...

Background: An association has been reported between hepatitis and glycogen storage problems. Glycogen disease (GSD) type I is induced by G6PD deficiency. Silymarin baicalein, as herbal agents, have hepatoprotective antioxidant potentials. Objectives: In this study, we assessed the effects of these herbs on liver problems hepatitis. Methods: Twenty male rats kept under standard laboratory condi...

Bioinorganic medicinal chemistry remains a hot field for research aimed at developing novel anti-cancer treatments. Discovery of metal complexes as potent antitumor chemotherapeutics such as cisplatin led to a significant shift of focus toward organometallic/ bioinorganic compounds containing transition metals and their chelates as novel scaffolds for drug discovery. In that way, transition met...