The effect of several hypoglycemic sulphonylureas upon the oxidative phosphorylation of intact rat liver mitochondria was examined. Following results were obtained and discussed in relation to hypoglycemic action and uncoupling site of these drugs. 1. All hypoglycemic sulphonylurea drugs tested, i.e., tolbutamide, carbutamide, chlorpropamide, acetohexamide, glybenclamide, and glyclopyramide wer...

BACKGROUND this study reports on the effectiveness of sitagliptin in Asian Indian type 2 diabetes patients seen at a tertiary diabetes care center who had inadequate glycemic control with oral hypoglycemic agents either alone or in combination, compared to a group of patients who received insulin glargine. PATIENTS AND METHODS patients with type 2 diabetes mellitus (n = 2,817) whose glycemia ...

Background: The use of autologous peripheral stem cell (PB-SCs) in Diabetes Mellitus type 1 (type 1 DM) was described in 2007 with promising conclusion. However a similar treatment with a positive outcome on type 2 diabetes mellitus patients (type 2 DM) has not been yet reported. The goal of this study was to determine the effect of autologous PB-SCs transplantation in treatment of DM2 patient....

The present study was carried out to evaluate oral hypoglycemic activity of rhizome of Hemidesmus indicus R.Br. in Albino wistar rats. Hemidesmus indicus (Family: Asclepiadaceae) is a commonly known Indian Medicinal Plant. It contains various phytoconstituents like hemidesminine, hemidine, hemidesmin-1 and hemidesmin-2 and other chemical constituents like glycosides, flavonoids, tannins, sterol...

there is some report about the hypoglycemic effect of juglans rejia l. leaf in alloxan induced diabetic rats and hypoglycemic effect of its fruit peel administered intra peritoneally. thirty male wistar rats divided into five groups, to evaluate the hypoglycemic and pancreas β-cells regenerative effects of oral methanolic extracts of leaf and fruit peel of walnut. rats were made diabetic by int...

A variable array of neuroglycopenic symptoms are frequently encountered in the hypoglycemic stage, but acute psychotic disorders are quite rare. A fifty five year old female presented with an acute psychosis following oral sulfonylurea induced hypoglycemia without preceding features of adrenomedullary stimulation. This case report suggests that an acute and transient psychotic disorder may be a...