In conjunction with other ONR HP investigators, we are performing an integrated study of the biogeochemical cycling of Cu, Cd, Zn, and Mn in the water column and sediments of a major US Naval harbor, the Elizabeth River (VA). We are studying the interrelationships among: (1) trace metal concentrations, complexation and speciation (Donat); (2) in situ production of Cu chelators by natural microb...

1. Díez JJ, Iglesias P. The role of the novel adipocyte-derived hormone adiponectin in human disease. Eur J Endocrinol. 2003;148:293-300. 2. Leth H, Andersen KK, Frystyk J, Tarnow L, Rossing P, Paeving HH, et al. Elevated levels of high-molecularweight adiponectin in type 1 diabetes. J Clin Endocrinol Metab. 2008;93:3186-91. 3. Oh DK, Ciaraldi T, Henry RR. Adiponectin in health and disease. Dia...

Abstract Background 64 Cu is one of the few radioisotopes that can be used for both imaging and therapy, enabling theranostics with identical chemical composition. Development stable chelators essential to harness potential this isotope, challenged by presence endogenous copper chelators. Pyridyl type show good coordination ability copper, prompting present study a series chelates DOTA-xPy (x =...

We have identified specific iron (Fe) chelators of the pyridoxal isonicotinoyl hydrazone (PIH) class that are far more effective ligands than desferrioxamine (DFO; Richardson et al, Blood 86:4295, 1995; Richardson and Milnes, Blood 89: 3025, 1997). In the present study, we have compared the effect of DFO and one of the most active chelators (2-hydroxy1-naphthylaldehyde isonicotinoyl hydrazone; ...

The transport properties of moisture and ionic chelators in the concrete affect not only durability concrete, but also effectiveness repair material repairing cracks concrete. water was investigated by capillary absorption tests ICP-OES (Inductively Coupled Plasma Optical Emission Spectrometer). It found that smaller radius pore within longer it takes to saturate with water.The different sizes ...

Recent developments in the understanding of the molecular control of iron homeostasis provided novel insights into the mechanisms responsible for normal iron balance. However in chronic anemias associated with iron overload, such mechanisms are no longer sufficient to offer protection from iron toxicity, and iron chelating therapy is the only method available for preventing early death caused m...