A simple one-pot and efficient synthetic method for the synthesis of pyrimido[4,5-c]pyridazine by a multicomponent reaction. The compounds are study their inhibitory activities towards AKT1 pathways using in silico method. It was found that all have binding energy lower than -7.9 kcal/mol compound 3a is most active with -9.65 kcal/mol, which been performed autodock vina.

Herein, we present a novel one-pot aqueous reaction for the synthesis of 2-iminothiazolines and 2-aminothiazoles using isocyanides, amines, sulfur, 2′-bromoacetophenones. The three-component preparation thioureas is followed by cyclization leading to heterocyclic product. This efficient mild procedure features excellent step- atom-economy enables chromatography-free diversely substituted 2-imin...

a series of 2-amino-4-(nitroalkyl)-4h-chromene-3-carbonitriles were synthesized by an efficient multicomponent reaction in aqueous media using dbu (1,8-diazabicyclo[5.4.0]undec-7-ene) as a catalyst at room temperature. mild condition, environment friendly procedure and excellent yields are the main advantages of this procedure. the cytotoxic activity of target compounds were evaluated against t...

Amidoalkyl-2-naphthols as synthetic intermediates play an important role in medicinal chemistry due to their remarkable biological and many pharmacological properties. Owing to the versatile biological activities, industrial and synthetic applications of these compounds, introduction of an alternative methodology is urgent in synthetic organic chemistry. Low yield and harsh reaction conditions ...