The present study examined the effects in mice of exposure to di(2-ethyl-hexyl) phthalate (DEHP) throughout pregnancy and lactation on the development and function of the pituitary-gonadal axis in male and female offspring once they have attained adulthood. Groups of two to three dams were exposed with the diet from gestational d 0.5 until the end of lactation, at 0, 0.05, 5, and 500 mg DEHP/kg...

In recent times male infertility and deteriorating semen quality has been an increasingly prevalent issue; researchers point towards changing environmental and lifestyle conditions as arguably the most significant cause of this phenomenon. Environmental and lifestyle exposure to a wide variety of factors may stress the male reproductive system throughout a man’s lifespan, from gestation to adva...

PURPOSE Controversy exists regarding the best approach to impalpable testes. We determined the usefulness of diagnostic laparoscopy for the management of impalpable testes. MATERIALS AND METHODS Between 2000 and 2008, 86 patients with a mean age of 34 months underwent diagnostic laparoscopy. An inguinal canal exploration was performed in all cases, except in patients in whom the internal sper...

M aking sperm in a culture dish has been a long-term goal of reproductive biologists. In 2010, a group of investigators from Yokohama, Japan, reinvestigated an organ culture system that was originally used for testicular tissue in the 1960s (1–3). By using better molecular markers, they were able to demonstrate that some cells in this culture system underwent complete meiosis to form round sper...

The study evaluated the role of imaging studies in the diagnosis of impalpable undescended testes. A total of 40 children referred with 45 impalpable undescended testes had an ultrasound scan and clinical examination by a pediatric surgeon. 22 out of these 45 testes were found to be palpable on clinical examination by a pediatric surgeon. Of the remaining 23 boys (23 units of testes), 21 underw...

background: post traumatic stress disorder (ptsd) in war veterans has been linked with symptoms in their children, including symptoms resembling those of the traumatized parents, especially aggression. this study aims to examine the effectiveness of cognitive-behavioral group therapy in reducing aggressive behaviors of male adolescents whose fathers have war related ptsd. method: 36 male childr...

Abstract Genes of the major histocompatibility complex (MHC) are crucial for adaptive immunity in jawed vertebrates, and theory predicts that there should be mate choice optimizing MHC constitution offspring. In a previous study, we demonstrated non-random female extra-pair males bluethroat ( Luscinia svecica ), yielding offspring was closer to an intermediate class II (MHCII) allele count than...

Hormone-sensitive lipase-knockout (HSL-/-) mice exhibit azoospermia for unclear reasons. To explore the basis of sterility, we performed the following three experiments. First, HSL protein distribution in the testis was determined. Next, transcriptome analyses were performed on the testes of three experimental groups. Finally, the fatty acid and cholesterol levels in the testes with three diffe...