Pain remains one of the main reasons for medical consultation worldwide: moderate- to severe-intensity pain occurs in 19% of adult Europeans, seriously affecting the quality of their social and working lives. Nonsteroidal anti-inflammatory drugs (NSAIDs) are not recommended for long-term use and a careful surveillance to monitor for toxicity and efficacy is critical. This study aims to assess: ...

Epidemiological studies indicate that long term use of nonsteroidal anti-inflammatory drugs (NSAIDs) confers protection from Alzheimer's disease, and some NSAIDs were shown to specifically decrease production of the amyloidogenic Abeta42 peptide, most likely by direct modulation of gamma-secretase activity. In contrast to gamma-secretase inhibitors, Abeta42-lowering NSAIDs do not impair S3 clea...

OBJECTIVES To discuss the clinical pharmacology of currently licensed veterinary NSAIDs and to review gastrointestinal and renal adverse effects as well as drug-drug interactions that have been reported with these drugs. To review the use of NSAIDs in the peri-operative setting and their use in patients with osteoarthritis. To further review the reported effects of NSAIDs on canine articular ca...

Paracetamol (acetaminophen) and the nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly used in children for antipyresis and analgesia. The anti-inflammatory properties of the NSAIDs have, in addition, been used in such diverse disorders as juvenile idiopathic arthritis, Kawasaki disease and cystic fibrosis (1–4). The NSAIDs indomethacin and ibuprofen are also used to treat delayed closu...

INTRODUCTION: Previous reports indicated that nonsteroidal anti-inflammatory drugs (NSAIDs) suppress bone repair in vivo. Our previous study further found that ketorolac suppressed bone repair at the early stage of endochondral ossification. Furthermore, we also found that NSAIDs suppressed osteoblast proliferation in vitro, which may be one of the important factors contributing to their inhibi...

The cardiovascular safety of COX-2 selective and nonselective nonsteroidal anti-inflammatory drugs (NSAIDs) has recently been called into question. The factors that predispose to adverse events by NSAIDs are unknown. Because patients with arthritis have decreased nitric oxide (NO) bioavailability, the in vivo effects of NSAIDs on murine vascular tone and platelet activity in the presence or abs...

The selective cyclooxygenase-2 (COX-2) inhibitors celecoxib and rofecoxib were designed to have similar efficacy but less gastrointestinal toxicity than traditional nonsteroidal anti-inflammatory drugs (NSAIDs). Their efficacy has been demonstrated in the treatment of osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, postoperative dental pain and dysmenorrhea. These agents produce f...