نتایج جستجو برای: nitration reaction

تعداد نتایج: 414200  

2014
Chloé Ackaert Stefan Kofler Jutta Horejs-Hoeck Nora Zulehner Claudia Asam Susanne von Grafenstein Julian E. Fuchs Peter Briza Klaus R. Liedl Barbara Bohle Fátima Ferreira Hans Brandstetter Gertie J. Oostingh Albert Duschl

Allergy prevalence has increased in industrialized countries. One contributing factor could be pollution, which can cause nitration of allergens exogenously (in the air) or endogenously (in inflamed lung tissue). We investigated the impact of nitration on both the structural and immunological behavior of the major birch pollen allergen Bet v 1.0101 to determine whether nitration might be a fact...

2010
Victor A. Mikhailov Jesus Iniesta Helen J. Cooper

Tyrosine nitration in proteins is an important post-translational modification (PTM) linked to various pathological conditions. When multiple potential sites of nitration exist, tandem mass spectrometry (MS/MS) methods provide unique tools to locate the nitro-tyrosine(s) precisely. Electron capture dissociation (ECD) is a powerful MS/MS method, different in its mechanisms to the "slow-heating" ...

2017
FM Strickland T Mau M O’Brien A Ghosh BC Richardson R Yung

OBJECTIVES Lupus flares are triggered by environmental agents that cause oxidative stress, but the mechanisms involved are unclear. The flares are characterized by oxidative modifications of proteins by 4-hydroxynonenals, malondialdehydes, carbonyls and nitration. These modifications have been proposed to induce and perpetuate lupus flares by "altered self" mechanisms. An epigenetically altered...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 1981
G A Olah S C Narang J A Olah

Naphthalene was nitrated with a variety of nitrating agents. Comparison of data with Perrin's electrochemical nitration [Perrin, C. L. (1977) J. Am. Chem. Soc. 99, 5516-5518] shows that nitration of naphthalene gives an alpha-nitronaphthalene to beta-nitronaphthalene ratio that varies between 9 and 29 and is thus not constant. Perrin's data, therefore, are considered to be inconclusive evidence...

Journal: :European Journal of Cancer 2022

Background: Nitrase Therapeutics is unlocking the therapeutic potential of nitrases, a new class enzymes discovered by company that catalyze post-translation modification called nitration. Materials And Methods: Nitrases nitration, process which an NO2 group transferred from peroxynitrite to specific tyrosines on substrates (nitro-substrates). Nitration important modifier protein structure, fun...

Journal: :Oriental journal of chemistry 2021

Conventional process of nitrating phenolic compounds involves the use excess corrosive reagents that impose environmental threats. Rapid and environmentally friendly microwave-assisted nitration phenol has been employed to limit nitric acid sulfuric acid. In this study, is reacted calcium nitrate acetic acid, which served as agents. The solution irradiated under microwave complete process. This...

2015
Gorakshanath B. Shinde Pravin K. Mahale Santhosh A. Padaki Navnath C. Niphade Raghunath B. Toche Vijayavitthal T. Mathad

An efficient, safe and improved process for the preparation of ticagrelor 1, a platelet aggregation inhibitor is described. Synthesis comprises the condensation of pyrimidine amine derivative 14 with cyclopentyl derivative 13 in ethylene glycol followed by construction of triazole compound 16 by diazotization of the obtained intermediate 15 with a green and safer reagent "Resin-NO2" in water an...

ژورنال: مواد پرانرژی 2016

Plasticizers are compounds which add to solid propellants’ formulations to improve their mechanical properties. These materials have key role in the control of mechanical properties. 2,4-Dinitrotoluene (2,4-DNT) is one of the most important plasticizers of double based propellants. In this study, new series of Brønsted acidic ionic liquids (ILs) have been prepared and introduced as...

2016
Capilla Mata-Pérez Juan C. Begara-Morales Mounira Chaki Beatriz Sánchez-Calvo Raquel Valderrama María N. Padilla Francisco J. Corpas Juan B. Barroso

In recent years, the study of nitric oxide (NO) in plant systems has attracted the attention of many researchers. A growing number of investigations have shown the significance of NO as a signal molecule or as a molecule involved in the response against (a)biotic processes. NO can be responsible of the post-translational modifications (NO-PTM) of target proteins by mechanisms such as the nitrat...

2012
Anette C. Karle Gertie J. Oostingh Sonja Mutschlechner Fatima Ferreira Peter Lackner Barbara Bohle Gottfried F. Fischer Anne B. Vogt Albert Duschl

Nitration of pollen derived allergens can occur by NO(2) and ozone in polluted air and it has already been shown that nitrated major birch (Betula verrucosa) pollen allergen Bet v 1.0101 (Bet v 1) exhibits an increased potency to trigger an immune response. However, the mechanisms by which nitration might contribute to the induction of allergy are still unknown. In this study, we assessed the e...

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