Alzheimer disease (AD) is a devastating neurodegenerative disease affecting more than five million Americans. In this study, we have used updated genetic linkage data from chromosome 10 in combination with expression data from serial analysis of gene expression to choose a new set of thirteen candidate genes for genetic analysis in late onset Alzheimer disease (LOAD). Results in this study iden...

The cover image is based on the Original Article Muscleblind-Like 2 knockout shifts adducin 1 isoform expression and alters dendritic spine dynamics of cortical neurons during brain development by Chia-Wei Huang et al., https://doi.org/10.1111/nan.12890.

You have accessJournal of UrologyProstate Cancer: Basic Research & Pathophysiology I (MP33)1 Sep 2021MP33-17 A GLUTAMINASE ISOFORM SWITCH DRIVES THERAPEUTIC RESISTANCE AND DISEASE PROGRESSION OF PROSTATE CANCER Lingfan Xu XuLingfan More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000002042.17AboutPDF ToolsAdd to favoritesDownload CitationsTrack Citations...

The fetal and early infant origins of a number of adult cardiovascular and metabolic diseases have received considerable attention, but the long-term consequences of early environments for human immune function have not been reported. We investigated the effects of pre- and postnatal environments on thymic hormone production in adolescents participating in an ongoing longitudinal study in the P...

Accurate allele specific expression estimation requires the availability of a diploid transcriptome, which makes it a challenging problem. Most existing methods rely on simple counting of alleles coverage at heterozygous Single Nucleotide Polymorphic sites. In this work, we present RNA-PhASE, a pipeline for Allele Specific gene and isoform Expression estimation from RNA-Seq Reads. The pipeline ...

Prion diseases are a group of infectious fatal neurodegenerative diseases. The conformational conversion of a cellular prion protein (PrP(C)) into an abnormal misfolded isoform (PrP(Sc)) is the key event in prion diseases pathology. Under normal conditions, the high-energy barrier separates PrP(C) from PrP(Sc) isoform. However, pathogenic mutations, modifications as well as some cofactors, such...

Heat shock factor 2 (HSF2) functions as a transcriptional regulator of heat shock protein gene expression in mammalian cells undergoing processes of differentiation and development. Our previous studies demonstrated high regulated expression and unusual constitutive DNA-binding activity of the HSF2 protein in mouse testes, suggesting that HSF2 functions to regulate heat shock protein gene expre...

BACKGROUND The deubiquitinase OTUB1 plays critical oncogenic roles and facilitates tumor progression in cancer. However, less is known regarding the aberrant expression, clinical significance and biological functions of the non-coding RNA OTUB1-isoform 2. We aimed to evaluate the OTUB1-isoform 2 levels in gastric cancer and their possible correlation with clinicopathologic features and patient ...