Methods Retrospective chart review of the clinical, laboratory, and radiographic features of SLE patients diagnosed before the age of 18 and followed at MSCHONY/CUMC in 2007-2009. Disease activity (SLEDAI) at diagnosis, occurrence of major infections, and Systemic Lupus International Collaborating Clinics Damage Index (SLICC) were evaluated. NPSLE was defined according to American College of Rh...

In this issue we present an exchange of views arising from the DSM-IV diagnostic criteria for delusions. Anchoring the discussion is an article by Drs. Mujica-Parodi and Sackeim in which they examine the DSM-IV requirement that to be classified as a delusion, a belief must be discordant with beliefs ordinarily accepted by the patient’s culture or subculture. They propose that an information-pro...

Because GABA appears to be an important, if not the primary, inhibitory neurotransmitter in brain, it is not surprising to find biochemical, physiological and behavioral data indicating that activation of the GABAergic system may be efficacious in the treatment of epilepsy (Meldrum, 1975). In addition, a significant loss of GABA neurons has been noted around the seizure foci in monkey cortex af...

International Neuropsychiatric Association As professional organizations go, the International Neuropsychiatric Association (INA) is young, having been formed in 1998 when a group of neuropsychiatrists met in Toronto, Canada, to consider the status of their profession. There was a shared sense of optimism, with a feeling that their time had come. They seemed ready to proclaim their professional...

The most common neuropsychiatric outcomes of stroke are depression, anxiety, fatigue, and apathy, which each occur in at least 30% of patients and have substantial overlap of prevalence and symptoms. Emotional lability, personality changes, psychosis, and mania are less common but equally distressing symptoms that are also challenging to manage. The cause of these syndromes is not known, and th...