The association of systemic lupus erythematosus and multiple myeloma is uncommon. We report two cases of systemic lupus erythematosus associated to multiple myeloma. The cases are discussed in the light of a review of the literature. The clinical, laboratory and radiographic findings of the patients, as well as the subsequent therapeutic approach are discussed. A systematic review of all the ot...

Objective The objective of this study was to investigate the association of clinical and renal disease activity with circulating sphingolipids in patients with systemic lupus erythematosus. Methods We used liquid chromatography tandem mass spectrometry to measure the levels of 27 sphingolipids in plasma from 107 female systemic lupus erythematosus patients and 23 controls selected using a desig...

INTRODUCTION To report on efficacy, tolerability and safety of rituximab in children with refractory autoimmune diseases. CASE PRESENTATION Five patients (juvenile dermatomyositis, Wegener's granulomatosis, systemic lupus erythematosus, myasthenia gravis and multiple sclerosis with systemic lupus erythematosus) were treated with rituximab and followed for a median time of 2.5 years. Two patie...

Few patients with systemic lupus erythematosus have features of verrucous (hypertrophic) lupus erythematosus. A 29-year-old Caucasian woman with a 7-year history of systemic lupus erythematosus developed painful verrucous plaques on the nose. Erythematous, raised, indurated, hyperkeratotic plaques localized on the dorsa of the distal parts of the toes and over the interphalangeal joints of her ...

Pregnancy is a physiological condition that requires immune tolerance to the product of conception. Systemic lupus erythematosus (SLE) is a disease with well-represented immune mechanisms that disturb immune tolerance. The association of pregnancy with systemic lupus erythematosus creates a particular immune environment in which the immune tolerance specific of pregnancy is required to coexist ...

how to cite this article: shiari r. neurologic manifestations of childhood rheumatic diseases.  iran j child neurol autumn 2012; 6(4): 1-7. children with rheumatic disorders may have a wide variety of clinical features ranging from fever or a simple arthritis to complex multisystem autoimmune diseases. information about the prevalence of neurological manifestations in children with rheumatologi...

background : progression of systemic lupus erythematosus (sle) could be due to oxidative stress especially through reactive oxygen species (ros). detoxification of ros is largely performed by glutathione s-transferases (gsts), therefore polymorphisms of gstm1, gstt1 and gstp1 genes which decrease enzymes activity could affect sle susceptibility. the aim of this study was to determine the effect...

background and objectives: bone marrow necrosis (bmn) is a rare and ominous complication of wide variety of diseases including hematologic malignancy. this study was performed to identify frequency and the underlying associated diseases of marrow necrosis. materials and methods: in this descriptive study, totally 850 bone marrow trephine biopsies related to living patients at the pathology depa...

The first description of lupus erythematosus was given by Pierre Louis Alphée Cazenave, who was a coworker of Laurent-Théodore Biett, in 1851. He used the French term “lupus erythemateux.” In 1856 Ferdinand Hebra translated this work into German and coined the term lupus erythematosus, which is the Latin translation, and in 1863 Isidor Neumann propagated the Greek term “lupus erythematodes.” In...

Fibromyalgia has been reported to occur with high prevalence in systemic lupus erythematosus. Data on fibromyalgia in other subsets of lupus erythematosus are not available. Risk factors for fibromyalgia have not been defined. We investigated 60 patients with different subsets of lupus erythematosus for the presence of fibromyalgia, association with clinical and laboratory parameters and diseas...