Biomarkers for increased cytogenetic damage in smokers include sister chromatid exchanges (SCE) in peripheral lymphocytes and micronuclei in sputum cells. These markers may reflect increased cancer risk. Increased cancer risk has also been associated with lower blood levels of the antioxidants beta-carotene and vitamin C and with genetic deficiency of the detoxification enzyme glutathione S-tra...

The juices of grapes (Vitis labrusca L.) are similar to the fruit itself because the main constituents of the fruit are present in the juice. However, their quality characteristics may be modified by the harsh technological processes used for the production of integral food, such as production systems of raw materials and post-harvest treatment of grapes with ultraviolet (UV) irradiation. There...

Agaricus blazei Murrill, a native mushroom in Brazil, has been widely consumed in different parts of the world due to its medicinal power. Its anticarcinogenic activity has been shown in experimental animals, and antimutagenic activity has been demonstrated only in Salmonella. In this work, the mutagenic and antimutagenic activities of mushroom teas of strains AB96/07, AB96/09 and AB97/11 were ...

The frequency of micronuclei in bone marrow cells of mice treated or not with Liv. 52 and then exposed to 4.5 Gy of gamma-radiation was evaluated from 6 h to 14 days post irradiation. The frequency of micronuclei increased from 6 h to 24 h post irradiated in both irradiated groups and declined thereafter, the frequency of micronuclei remaining significantly lower in the Liv. 52-treated group. T...

methotrexate is an antineopalstic agent widely used in low dose to treat patients with rheumatoid arthritis. it is known to induce micronuclei at multiple doses in rats. the present study investigates the effect of vitamin a on methotrexate-induced micronuclei in rat bone marrow erythrocytes. male wistar rats were (n=5) injected with 0, 8, 16 and20mg/kg methotrexate (single i.p dose). a group o...

The cytokinesis-block micronucleus assay is a sensitive and simple indicator of chromosome damage, both chromosome loss and chromosome breakage, which also provides information on cell cycle progression and cytotoxicity. It was introduced in 1985 and has been successfully employed in many laboratories on different cell types to monitor exposed population, to identify mutagen-sensitive individua...

Methotrexate is an antineopalstic agent widely used in low dose to treat patients with rheumatoid arthritis. It is known to induce micronuclei at multiple doses in rats. The present study investigates the effect of vitamin A on methotrexate-induced micronuclei in rat bone marrow erythrocytes. Male wistar rats were (n=5) injected with 0, 8, 16 and20mg/kg methotrexate (single i.p dose). A group o...

The overall response to TBA and TBAC in genetic toxicology assays is very weak to negative. There are only three papers that are relevant to TBA with purported positive responses. These results are far out-numbered by negative results in the mouse lymphoma assay, Chinese hamster ovary assessment for SCEs, aberrations and micronuclei, and negative responses in Salmonella TA 98, 100, 104, 1535, a...

The raw data showed in this article comes from the published research article entitled "Protective effects of Chlorogenic acid in 3-Nitropropionic acid induced toxicity and genotoxicity" Food Chem Toxicol. 2017 May 3. pii: S0278-6915(17)30226-0. DOI:10.1016/j.fct.2017.04.048. [1]. Data illustrates antitoxic and antigenotoxic effects of Chlorogenic acid (CGA) on toxicity and genotoxicity produce...

The use of vegetal extracts requires toxicological and genotoxic evaluations to establish and verify safety before being added to human cosmetic, pharmaceutical medicine, or alimentary products. Persea americana seeds have been used in traditional medicine as treatment for several diseases. In this work, the ethanolic seed extract of Persea americana was evaluated with respect to its genotoxic ...