This note studies the number of positive steady states in biomolecular reactions consisting of activation/deactivation futile cycles, such as those arising from phosphorylations and dephosphorylations at each level of a MAPK cascade. It is shown that (1) for some parameter ranges, there are at least n + 1 (if n is even) or n (if n is odd) steady states; (2) There never are more than 2n steady s...