Introduction: High dose of acetaminophen (APAP) is known to have hepatotoxic and nephrotoxic effects and studies show that this toxicities are dependent on the function of phase I bioactivation enzymes- Cyp450- and phase II biotransformation enzymes especially glucuronosylation and sulfonation pathways. However, the role of cyclooxygenase (COX) as an inflammatory mediator in toxic effects of AP...

objective(s):to evaluate the effect of trinitroglycerin (tng) as nitric oxide donor agent on serum copper (cu) and zinc (zn) levels and liver enzymes in balb/c mice infected with leishmania major (l. major) mrho/ir/75/er. materials and methods: inbred female mice were divided into three groups: healthy group (uninfected naive mice), control group (infected with l. major), and test group (l. maj...

background: to compare the pathogenicity differences in two susceptible balb/c and resistant c57bl/6 mice infected with leishmania major mrho/ir/75/er as a prevalent strain of zoonotic cutaneous leishmaniasis in iran. methods : mice were assigned into four groups as control and infected balb/c and c57bl/6 mice. experimental leishma­niasis was initiated by (s. c) injection of the 2×10 6 l. major...

Wilson disease (WD), known as hepatolenticular degeneration (HLD), is a treatable autosomal recessive disorder of copper metabolism. Because deposits in the liver first, not only original defective organ but also most affected organ. The injury one main causes death throughout course disease. Therefore, treatment task WD treatment, which great significance to improve prognosis patients. Autopha...

Introduction: Piperine is a compound that has many health benefits, but piperin toxic effects endanger the human body. The purpose of this study was to determine dose subchronic piperine administration using histology liver, kidneys, and lungs mice (Mus musculus L).Method: This quasi-experimental research with posttest only control group design. Thirty male BALB/c were divided into five groups....

Background and purpose Heavy alcohol drinking-induced alcoholic fatty liver, steatohepatitis, early-stage liver fibrosis may progress to advanced-stage (AALF)/cirrhosis. The lack of non-invasive imaging techniques for the diagnosising collagenogenesis in activated hepatic stellate cells (HSCs) can lead incurable at early reversible stage. Proline has been known as most abundant amino acid colla...

objective: pseudomonas aeruginosa is the major cause of septicemia and wound infection in burned patients. immunotraphy is the best practical way for prevention and treatment of these infections. flagella as one of the most important bacterial virulence factors has important role in attachment, motility, chemotaxis and tlr-5-dependent immune response so that it propounded as a vaccine candidate...

Objective(s):Fuzheng Huayu recipe (FZHY) exerts significant protective effects against liver fibrosis by strengthening the body’s resistance and removing blood stasis. However, the molecular mechanisms through which FZHY affects liver fibrosis are still unclear. In this study, we examined the expression levels of factors involved in the inhibitor κB kinase-β (IKK-β)/nuclear factor-κB (NF-κB) an...