Introduction: Celastrus paniculatus seed oil, commonly known as Malkangni or Jyotishmati, was in use from time immemorial to treat brain related disorders. Celastrus paniculatus seed oil has significant antidepressant-like activity in chronic unpredictable stressed mice. The present study was undertaken to evaluate the antidepressant-like effect of Celastrus paniculatus seed oil ...

When tobacco is smoked, chewed or snuffed, nicotine is absorbed by the lungs or mucous membrane and quickly moved into the bloodstream, where it is circulated throughout the brain. In fact nicotine is highly dangerous to be consumed in any form. The present study was conducted to know the adverse effects of nicotine on the platelet aggregation in cerebral microvessels of mice. Male mice of aver...

Abstract Background and Aims Acute kidney injury (AKI) is a very common condition in inpatients. Severe AKI frequently associated with by neurological disorders such as confusion, the mechanisms of which are poorly understood. We have shown several animal models that chronic disease impaired cognitive performance memory increased permeability blood-brain barrier (BBB), related to accumulation u...

Background: Biochanin A is an excellent dietary isoflavone that has the concomitant function of both medicine and foodstuff. The attenuation biochanin on blood-brain barrier (BBB) damage induced by cerebral ischemia-reperfusion remains unclear. Methods: C57BL/6 mice were subjected to 1 h middle artery occlusion (MCAO) followed 24 reperfusion. infarct volume brain was stained TTC, ...

Abstract Background Social isolation rearing (SIR) is a developmental schizophrenia model with characteristic behavioral symptoms like anxiety and olfactory deficits influenced by the amygdala bulbs respectively. Psychiatric disorders dementias are often comorbid, neuropsychiatric disturbances constituting inherent component of Alzheimer’s. As long‐term side effects mar available antipsychotics...

Background: Spermatogenesis associated 19 (Spata19) was introduced as a testis-specific gene that probably involved in spermatogenesis cell apoptosis. Therefore, this study aimed to investigate the effect of Spata19 inactivation on sperm count. Materials and Methods: We generated global knockout mice by CRISPR/Cas9 nickase technology. Disability validated three levels DNA, RNA, protein using PC...

• Post-weaning/adolescent social isolation increased ?FosB in the cortex and hippocampus of adult mice. FosB was also isolated females. Short-term stress has persistent effects on brain that depend sex. Social is a growing public health concern across lifespan. Specifically, early life, during critical periods development, increases risk psychiatric disorders later life. Previous studies models...

background: brain is the most important organ as it controls and co- ordinates all the activities of our body. reports on neuroethological investigations in mice particularly associated with learning and memory after radiation exposure are very scanty. hence, present investigation is an attempt to examine the effects of low dose tritiated water (hto) acute exposure on adult swiss albino mice in...

sodium valproate and tomato extract have been studied in different experimental models of epilepsy individually. the aim of the present study was to evaluate the effect of lycopene on the antiepileptic effects of sodium valproate against pentylenetetrazol-induced kindling in mice. swiss albino mice of either sex were randomly divided into 5 groups, with each group containing 8 mice. these group...

Cortical spreading depression is a pathophysiological event shared in migraines, strokes, traumatic brain injuries, and epilepsy. It associated with complex hemodynamic responses, which, turn, contribute to neurological problems. In this study, we investigated the role of canonical transient receptor potential channel 3 (TRPC3) responses elicited by cortical depression. Cerebral blood flow was ...