conclusions: lymphatic metastasis in patients with oral and maxillofacial scc is closely related to the positive expression of vegf, mmp-9 and timp-2. mmp-9 and timp-2 can affect the progression of cancer, which is valuable for studies on oral and maxillofacial scc genes. objectives: to explore the association between expression of vegf, mmp-9 and timp-2 in oral and maxillofacial scc and clinic...

background: a soluble form of her-2/neu extracellular domain (sher-2) is reported to be released in the sera of metastatic breast cancer patients. objective: to measure the level of sher-2 in sera of 115 breast cancer patients. methods: serial samples of 27 patients with metastasis, 18 non-metastatic patients, 15 patients in stage 0/i and 14 patients with accompanying benign breast disease were...

the paranasal sinuses are known to be a rare location for metastasis. renal cell carcinoma (rcc) is the most frequent primary tumor to metastasize to the sinonasal region, followed by lung and breast cancer. in particular, clear cell type rcc, which represents approximately 85% of rccs, is characterized by early metastasis, and it sometimes spreads to unusual sites (1, 2). metastatic tumors in ...

although splenic metastasis is fairly common in disseminated cancer, solitary splenic metastasis in the absence of diffuse dissemination is rare. we report a case of 44 year-old man who developed isolated splenic metastasis of colon cancer. the patient had undergone right sided hemicolectomy for colon cancer in 1988. in 2001, he underwent reoperation because of local recurrence of tumor in the ...

Thyroid gland metastatic tumors are rare in clinical practice. Clear cell RCC is one of common metastatic tumors to thyroid. We here reported a case of incidentally found clear cell renal carcinoma metastasis to the thyroid gland 3 years after nephrectomy, in the thyroidectomy procedure performed for the patient due to the thyroid enlargement caused by multinodular goiter. A 65-year-old Iranian...

background: the beginning of metastasis poorly affects the prognosis of breast cancer patients. lung is the most frequent site of visceral metastasis, and the rate of recurrence is 10-30%. we have tried to find out if the routine chest x ray (cxr) could play a role for early detection of lung metastasis, during the prognosis of these patients. methods: the files of the breast cancer patients be...

Background: The First apoptosis signal (FAS) and First apoptosis signal ligand (FASL) genes initiate the apoptosis pathway, playing a central role in the tumor growth and metastasis. Gene polymorphisms including -1377 G/A in the promoter region of FAS and -844 C/T in the promoter region of FASL have shown to change the transcription activities of these genes. Methods: In this study we evalua...

Background: Malignant pleural effusion is common in patients with advanced malignant tumor. The aim of this study is to analyze the characteristics of pleural metastasis of renal clear cell carcinoma, pleural effusion under medical thoracoscopy and the diagnostic value of interventional thoracoscopy-guided biopsy, and to improve the understanding of pleural metastasis of renal clear cell carcin...