In this study, we have investigated how the function of native and recombinant nicotinic acetylcholine receptors (nAChRs) is modulated by the monoterpenoid alcohol from peppermint (-) menthol. In trigeminal neurons (TG), we found that nicotine (75 μM)-activated whole-cell currents through nAChRs were reversibly reduced by menthol in a concentration-dependent manner with an IC₅₀ of 111 μM. To an...

Capsaicin and menthol are the most extensively studied of all chemesthetic agents. Capsaicin is best known as a nociceptive stimulus and menthol as an artificial cooling agent, but both have a combination of thermal and nociceptive properties. Capsaicin can affect perception of nonpainful warmth and heat as well as burning pain and menthol can induce burning and stinging as well as cold. Howeve...

UNLABELLED The transient receptor potential cation channel subfamily M 8 (TRPM8) agonist L-menthol has been used traditionally for its topical counterirritant properties. Although the use of topical L-menthol for pain is casuistically established, evidence regarding its efficacy is negligible. This study aimed to characterize the effect of L-menthol as a counterirritant on cutaneous pain and hy...

Menthol is widely used as a fragrance and flavor in the food and cosmetic industries. It is also used in the medical and pharmaceutical fields for its various biological effects. Gas chromatography (GC) is considered to be a sensitive method for the analysis of menthol. GC chromatographic separation was developed using capillary column (VF-624) and a flame ionization detector (FID). The method ...

Since the 1920s, menthol has been added to cigarettes and used as a characterizing flavor. The health effects of cigarette smoking are well documented, however the health effects of menthol cigarettes as compared to non-menthol cigarettes is less well studied. This review discusses menthol's effects on 1) biomarkers of tobacco smoke exposure, 2) toxicity and cellular effects, 3) lung function a...

interaction of menthol with polyethylene terephthalate bottles during storage time was tested at three different temperatures. menthol is a mint flavor agent added to yogurt drinks in iran and is considered as a factor affecting consumer acceptance. absorption of menthol to packaging material could cause a loss of quality in the final product due to diminished flavor intensity. tests were done ...

(−)-Menthol is one of the most popular aroma compounds worldwide. While in past mostly extracted from mint plants, today (−)-menthol synthesis other raw materials becoming more relevant. Common starting for menthol are m-cresol, citral and myrcene, but also substrates like menthone, mono- bicyclic terpenes terpenoids have been used this purpose past. As many applications high purity required, a...

Menthol is used as a constituent of food and drink, tobacco and cosmetics nowadays. This cold receptor agonist has been used as a nasal inhalation solution in the daily life. The effect of menthol on nasal mucosa in vivo is well known; however, the effect of the drug on tracheal smooth muscle has been rarely explored. Therefore, during administration of the drug for nasal symptoms, it might als...

PURPOSE Bladder outlet obstruction (BOO) causes storage and voiding dysfunction in the lower urinary tract. We investigated the expression of transient receptor potential cation channel subfamily M member 8 (TRPM8) to evaluate the relationship between TRPM8 expression and overactive bladder (OAB) in a rat model of BOO. METHODS Fifty female Sprague-Dawley rats were divided into 4 groups; norma...

OBJECTIVE To examine what the tobacco industry knows about the potential effects menthol may have on nicotine dependence. METHODS A snowball strategy was used to systematically search the Legacy Tobacco Documents Library (http://legacy.library.ucsf.edu/) between 22 February and 29 April, 2010. Of the approximately 11 million documents available in the Legacy Tobacco Documents Library, the ite...