نتایج جستجو برای: mcf7 cells
تعداد نتایج: 1383829 فیلتر نتایج به سال:
Although the epithelial-mesenchymal transition (EMT) is a normal process that occurs during development, it is thought to be associated with cancer progression and metastasis. Emerging evidence links mesenchymal stem cells (MSCs) in the tumor microenvironment with the occurrence of EMT in cancer progression. In this study, the human breast cancer cell line MCF7 was co-cultured with human adipos...
Here, we developed an isogenic cell model of "stemness" to facilitate protein biomarker discovery in breast cancer. For this purpose, we used knowledge gained previously from the study of the mouse mammary tumor virus (MMTV). MMTV initiates mammary tumorigenesis in mice by promoter insertion adjacent to two main integration sites, namely Int-1 (Wnt1) and Int-2 (Fgf3), which ultimately activates...
Jadomycins are natural products biosynthesized by the bacteria Streptomyces venezuelae which kill drug-sensitive and multidrug-resistant breast cancer cells in culture. Currently, the mechanisms of jadomycin cytotoxicity are poorly understood; however, reactive oxygen species (ROS)-induced DNA cleavage is suggested based on bacterial plasmid DNA cleavage studies. The objective of this study was...
A multistep synthesis was developed to prepare new 1,2,3-triazole-amino acid conjugates (6 and 7). These compounds contain the diaryl ether moiety were synthesized via SNAr reaction under mild condition in good yield. Their structures confirmed by spectroscopic analyses (HR-MS, NMR, IR). showed significant antiproliferative activity (>30%) toward breast MCF7 liver HepG2 cancer cells lines at...
Abstract Nanomaterials are attracting increasing interest in many biomedical fields, including the fight against cancer. In this context, we successfully synthesized CoNi alloy nanoparticles (NPs) by a simple polyol process. The magnetic characteristics of products were measured vibration sample magnometry, which revealed that samples have soft ferromagnetic behavior. microstructure and morphol...
Cell lines and reagents: Matrigel was from BD Biosciences. The highly metastatic lung-tropic MDA-MB231 subline 4175 was kindly provided by Dr. J. Massague [1]. MCF10A, 4T1, and 4T07 cells were kindly provided by Dr. Fred Miller (Karmanos Cancer Institute, MI). BT20 and MCF7 were purchased from ATCC. 4T1, and 4T07 cells were cultured in Dulbecco’s modified Eagle’s medium with 5% FBS, 5% newborn ...
Breast cancer resistance to the antiestrogens tamoxifen (OHT) and fulvestrant is accompanied by alterations in both estrogen-dependent and estrogen-independent signaling pathways. Consequently, effective inhibition of both pathways may be necessary to block proliferation of antiestrogen-resistant breast cancer cells. In this study, we examined the effects of apigenin, a dietary plant flavonoid ...
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