Dooley described patients with frequent manic attacks as being headstrong, selfsufficient, know-it-all types of people who will get the upper hand of the analyst. Gibson noted that while manic-depressive individuals appear remarkably insensitive to interpersonal subtleties on a conscious level, they can be extraordinarily perceptive on a subconscious or unconscious one. He felt that these patie...

BACKGROUND Genes encoding proteins involved in serotonergic metabolism are major candidates in association studies of mood disorders and suicidal behavior. This association study explores whether the tryptophan hydroxylase (TPH) gene, which codes for the rate-limiting enzyme of serotonin biosynthesis, is a susceptibility factor for manic-depressive illness, with or without a history of suicide ...

Manic-depressive illness (bipolar disorder) afflicts approximately 2.3 million American adults. Although earnings, unemployment, and labor force participation patterns have been analyzed for manic-depressives in the economics literature, occupational choice has yet to be explored. A number of psychiatric studies link bipolar illness and occupational choice, focusing on occupational creativity. ...

True or pure depressions as seen in adult are very rare in children. However, recently, there have been many reports from various psychiatric clinics about childhood depressions and it has been more or less accepted as a clinical entity though not yet included in official classification. Historically sadness or despondency in children was recognised in the 17th century and suicide and melanchol...

This study investigated the psychiatric consequences of 38 consecutive patients who had surgery for intractable temporal lobe epilepsy with special attention to postoperative mood disorders. A close interrelation between preoperative postictal psychosis and postoperative manic or depressive episodes was suggested. Left sided lobectomy augmented this correlation. Because the first sign of postop...

Various reports have described increased serum creatine kinase (CK) activity in the majority of hospitalized acutely disturbed schizophrenics and patients with affective psychoses. We investigated CK serum levels of 52 unmedicated bipolar inpatients, in manic versus depressive states. Additional 17 patients were evaluated in both states. Hamilton Rating Scale for Depression and Young Mania Rati...