Inhibition of mitochondrial carnitine palmitoyltransferase I (CPT I) by malonyl-CoA, the product of the acetyl-CoA carboxylase reaction, was first recognized in 1977 during the course of studies on hepatic ketogenesis and its regulation [ l ] . What emerged from that work was that with carbohydrate feeding (high insulin/low glucagon) the liver is actively engaged in fatty acid biosynthesis, the...

ABSTRACT. 2-N,N-dimethylamino-2-oxido-3-alkyl(aryl)-1-hydro-2-benzo[1,3,2]diazaphosphinin-4-one (2) derivatives are synthesized by one pot reaction reacting equimolar quantities of anthranilic acid, primary amine, and N,N-dimethylphosphoramic dichloride under reflux ethanol with good yields. The structure the compounds were established on basis their infrared, nuclear magnetic resonance spectra...

The nitridotungsten(vi) complex NW(N[i-Pr]Ar)(3) (-N, Ar = 3,5-Me(2)C(6)H(3)) reacts with (CF(3)C(O))(2)O followed by ClSiMe(3) to give the isolable trifluoroacetylimido-chloride complex -(NC(O)CF(3))Cl, with oxalyl chloride to give cyanate-dichloride -(OCN)(Cl)(2), and with PCl(5) to give trichlorophosphinimide-dichloride -(NPCl(3))(Cl)(2). The oxo-chloride complex -(O)Cl, obtained from -N upo...

background: paraquat dichloride is a highly toxic herbicide which is still used in many developing countries. african cat fish (clarias gariepinus) is a commercially important species in many countries and was selected assess accumulation and elimination of paraquat dichloride in its tissues. methods: groups of ten fish with equal lengths and weights were exposed to varying concentrations of pa...

A general approach for the synthesis of bis(imidazolium) dichloride salts from imidazoles and dichloroalkanes is reported. Typical limitations this reaction formation methylene-bridge...

A yeast system differs only in that the major product is stearylCo.4 (5, 6) rather than the free fatty acid, palmitate, as in the other systems. The fatty acid synthetase reaction appears to be a multistage reaction catalyzed by a particulate enzyme complex estimated to have a molecular weight of 2,000,OOO in yeast (6) and to be readily sedimentable by ultracentrifugation in adipose tissue (4) ...

In this issue of the JCI, Rasmussen et al. (1) describe the functional regulation of fatty acid oxidation by hyperglycemia and hyperinsulinemia in human skeletal muscle. The authors report inhibition of long-chain fatty acid (LCFA) oxidation, but not medium-chain fatty acid (MCFA) oxidation, in association with increased intramyocellular malonyl-CoA concentrations. Normally, a glucose infusion ...

A yeast system differs only in that the major product is stearylCo.4 (5, 6) rather than the free fatty acid, palmitate, as in the other systems. The fatty acid synthetase reaction appears to be a multistage reaction catalyzed by a particulate enzyme complex estimated to have a molecular weight of 2,000,OOO in yeast (6) and to be readily sedimentable by ultracentrifugation in adipose tissue (4) ...

In non-racemic (1R,2R)-(1,2-dialkyl)-1,2-diaminocyclohexane palladium dichloride complexes the C2 symmetry of the diamine ligand is broken, resulting in selective R,S-coordination.