BACKGROUND Small deposits of amyloid are often found in the hearts of elderly patients. However, extensive deposition of transthyretin-derived amyloid fibrils in the heart (senile systemic amyloidosis [SSA]) can cause heart failure. The clinical features of SSA that involve the heart are ill defined, and the condition may be overlooked as a cause of heart failure. We sought to better define the...

BACKGROUND AND OBJECTIVES Light chain (AL) and secondary (AA) amyloidosis usually present as a systemic disease frequently involving the kidney and leading to ESRD. Data regarding patients with AA or AL amyloidosis undergoing dialysis remain scarce. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS We retrospectively studied patients with AA or AL amyloidosis who started dialysis in five French c...

S ystemic amyloidosis is a relatively rare multisystem disease caused by the deposition of misfolded protein in various tissues and organs. It may present to almost any specialty, and diagnosis is frequently delayed.1 Cardiac involvement is a leading cause of morbidity and mortality, especially in primary light chain (AL) amyloidosis and in both wild-type and hereditary transthyretin amyloidosi...

AA amyloidosis is a disorder characterized by the abnormal formation, accumulation and systemic deposition of fibrillary material that frequently involves the kidney. Recurrent AA amyloidosis in the renal allograft has been documented in patients with tuberculosis, familial Mediterranean fever, ankylosing spondylitis, chronic pyelonephritis and rheumatoid arthritis. De novo AA amyloidosis is ra...

Amyloidosis is a relatively rare disease that may be underdiagnosed and could affect the entire human body. Many organs may be affected, which could increase the morbidity and mortality. Cardiac involvement is the leading cause of poor prognosis. Patients with cardiac amyloidosis are usually admitted with heart failure. The clinical presentation varies greatly, and using the correct approach is...

A 54-year-old man with polycystic liver disease received a domino liver transplantation (DLT) from a patient of hereditary ATTR amyloidosis with the transthyretin Ser50Arg mutation. Ten years after transplantation, he felt a slight numbness in his toes, and cardiac amyloidosis was simultaneously suspected upon a heart function evaluation. Biopsy specimens from the myocardium revealed transthyre...

Amyloidosis is a benign, slowly progressive condition characterized by the presence of extracellular fibrillar proteins in a variety of organs and tissues. It can be categorized as systemic or localized. Head and neck involvement can be seen in both systemic and localized amyloidosis. Systemic amyloidosis results in involvement of many organs, and shortens life expectancy, whereas localized amy...

Amyloidosis is a disorder of protein metabolism which is characterized by deposition of eosinophilic material intercellularly which has characteristic ultra-structural morphology and biochemical features. Amyloidosis may be primary but more often it is secondary to various inflammatory, neoplastic and suppurative conditions. Inflammatory bowel disease is an unusual cause for secondary amyloidos...

Amyloidosis is a rare disease with an incidence of approximately 6–10 cases per million person years. It is defined as tissue deposition of fibrils consisting of different types and weight of normal serum proteins’ subunits. Amyloidosis disease can involve different organs depending on the subtype. Amyloidosis frequently affects the heart, kidneys, gastrointestinal organs and nervous system. Am...