Background: Decitabine (5-aza-2'-deoxycytidine, DAC) is a deoxycytidine analog currently used as an effective drug against myelodysplastic syndromes and acute myeloid leukemia. Although various studies have pointed out the epigenetic effects of this drug, its epigenetic mechanisms in different leukemic cell lines are not specified. In this lab trial study, possible epigenetic effects of decitab...

We present a 52-year-old man who was diagnosed with B cell-derived angioimmunoblastic lymphoma. He was admitted with systemic, including mediastinal and para-aortic, lymphadenopathy, fever and skin itching. Histologically, his lymph nodes showed total obliteration of the normal architecture by a polymorphic infiltrate of large-sized lymphocytes with proliferation of arborizing small blood vesse...

Concentration dependence of mutation in equigenerational exposures to methyl, ethyl, propyl, and butyl methanesulfonates has been determined in diploid human lymphoblasts and Salmonella typhimurium. Forward mutation was measured at the hypoxanthine guanine phosphoribosyltransferase locus in human lymphoblasts and at the putative guanine phosphoribosyltransferase locus in S. typhimurium. Reverse...

We developed a stroma cell culture system that suppresses apoptosis of malignant cells from cases of B-lineage acute lymphoblastic leukemia. By multiparameter flow cytometric measurements of cell recovery after culture on stromal layers, we assessed the growth potential of 70 cases of newly diagnosed B-lineage acute lymphoblastic leukemia and related the findings to treatment outcome in a singl...

Since the possibility of interruption of latent EBV infection has been suggested by the induction of the lytic virus cycle with chemical substances, other viruses, and by immunosuppression, we hypothesized that the same effect might happen in B. burgdorferi sensu lato infection as happens in Lyme disease patients with positive serology for both agents. We have observed EBV replication in lympho...

A 32-year-old man 5 years previously received allogeneic bone marrow transplantation from his mother for Philadelphia chromosome positive acute lymphoblastic leukemia. He presented with headache, nausea, and pain in the left arm. The neurologic examination revealed no abnormalities except for stiffness of the neck. Gadolinium-enhanced T1weighted magnetic resonance imaging (MRI) showed diffuse c...

We present a case of bilateral serous retinal detachment (SRD) as a presenting sign of Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph(+) ALL). A 45-year-old woman presented with decreased vision and was found to have bilateral serous retinal detachment. Peripheral blood smears revealed leukocytosis of 53.9x10(3)/microL with 64.6% lymphoblasts. A bone marrow aspirate revealed ...