BACKGROUND Low levels of total 25-hydroxyvitamin D are common among black Americans. Vitamin D-binding protein has not been considered in the assessment of vitamin D deficiency. METHODS In the Healthy Aging in Neighborhoods of Diversity across the Life Span cohort of blacks and whites (2085 participants), we measured levels of total 25-hydroxyvitamin D, vitamin D-binding protein, and parathyr...

Conventional emulsions are heterogeneous system in which one immiscible liquid is dispersed as droplets in another liquid. That may be water-in-oil or oil-in-water emulsions. However emulsion can be formulated waterless or without an aqueous phase to produce anhydrous or non-aqueous or oil-in-oil emulsions may be used as reservoirs to deliver lipophilic or hydrolytically unstable drugs, could b...

Atorvastatin calcium, a lipid-lowering drug, is much less bioavailable because of reduced solubility in acidic media. Multiple-unit floating microcapsules of Atorvastatin calcium (ATC) were developed to expand the gastric residence time of the drug, as ATC has maximum rate of absorption in the upper GI tract. Floating microcapsules were prepared by Emulsion-solvent evaporation technique through...

Sex hormone binding globulin (SHBG) is a protein that binds to both testosterone and estradiol. Its amount can vary widely in patients, and if the SHBG is either low or high, the amount of active (bioavailable) testosterone can vary widely. Therefore, it is very important to measure SHBG in all patients being evaluated for polycystic ovarian syndrome, as well as other patients such as patients ...

Lead (Pb) poisoning causes permanent neurologic and developmental disorders and remains an important environmental health problem for US children, despite removal of Pb from gasoline and household paints. To better understand the contribution of Pb from historical traffic and residential Pb based paint to soil Pb concentrations in Los Angeles, we analyzed 550 soil Pb samples from south central ...

OBJECTIVE We examined whether high waist-to-hip ratio (WHR) in women is a biomarker for increased testosterone (T) and higher levels of sexual desire. METHODS Participants were 99 healthy nonobese premenopausal women. Trait levels of mean bioavailable T were estimated from three saliva samples collected at 8:00 am, 9:30 am, and 6:00 pm to 9:00 pm, controlling for phase of the menstrual cycle....

Many women, both before and after menopause, may have symptoms of androgen deficiency: unexplained fatigue, lack of well-being and diminished libido. If plasma levels of bioavailable testosterone are low, these symptoms will mostly be relieved by judicious administration of testosterone. The addition of testosterone to postmenopausal hormone replacement regimens is becoming more widespread, and...

We investigated the suitability of an active biomonitoring approach, using the ecologically relevant species Gammarus fossarum, to assess trends of bioavailable contamination in continental waters. Gammarids were translocated into cages at 27 sites, in the Rhône-Alpes region (France) during early autumn 2009. Study sites were chosen to represent different physico-chemical characteristics and va...

The diagnosis of late life hypogonadism is controversial. For the purposes of discussion, it is suggested that treatment of late life hypogonodism requires the presence of symptoms, a low level of circulating free or bioavailable testosterone level and a positive response to treatment. While this may appear to be a radical proposal, we believe it represents the most rigorous scientific approach...

Monkeypox is a zoonotic viral infection caused by monkeypox virus which belongs to the Poxviridae family of genus Orthopoxvirus. Usually, transmission happens when individual comes in contact with infected person through body fluids, animal lesions, respiratory droplets or contaminated materials. Clinical presentation has shown significant resemblance that smallpox and chickenpox, belonging sam...