The theory of clinical depression presented here integrates etiological factors, changes in specific structural and cellular substrates, ensuing symptomatology, and treatment and prevention. According to this theory, important etiological factors, such as stress, can suppress the production of new neurons in the adult human brain, thereby precipitating or maintaining a depressive episode. Most ...

The active sites of Cyt. P450s contain a single heme b cofactor with a proximal cysteinate ligand. Figure 1 shows the active site of P. putida Cyt. P450cam as an example. The catalytic mechanism of Cyt. P450s has been studied in detail and is depicted in Figure 1. After one-electron reduction of the heme, O2 is bound first and subsequently reduced and protonated, generating an Fe–OOH complex (C...

The great blues singer Etta James’ signature song begins, “At laaasst, my love has come along . . . .” This may have been the feeling on May 4th when NASA announced the long-awaited results of Gravity Probe B [1], which are appearing now in Physical Review Letters[2]. Over 47 years and 750 million dollars in the making, Gravity Probe B was an orbiting physics experiment, designed to test two fu...

In this issue of Blood, Wang et al reveal that ligation of Ly6G on murine neutrophils inhibits neutrophil recruitment, providing the first evidence of a function for this molecule.

Since the presentation of trials such as the Intergroup N9741 study (National Cancer Institute of Canada CO.15) and the MOSAIC (Multicenter International Study of Oxaliplatin/5-FU–LV in the Adjuvant Treatment of Colon Cancer) trial at the 2003 American Society of Clinical Oncology meeting, oncologists have broadly accepted that oxaliplatin is part of the standard management of colorectal cancer...