As has already been extensively commented in the article on antihistamines and the central nervous system, published in this same issue, all the classical antihistamines and, to a lesser extent, the more recent synthetic compounds are able to exert depressive action upon the central nervous system (CNS), causing drowsiness, lassitude, dizziness, incoordination, and increased reaction time. More...

A boy aged 7 was admitted to hospital after having vomited a small quantity of blood on two occasions during the preceding day without warning or preceding nausea. For six days he had been ill with a sore throat, lassitude and malaise, while the left side of his face and neck had developed a swelling which suggested a diagnosis of mumps. The boy was pale and inert. He showed a mild pyrexia (100...

US government work, not subject to copyright Pharmacokinetic data are now available for the absorption, plasma concentrations and renal excretion of vitamin C. With these new insights, it is worth reconsidering the clinical role of vitamin C in scurvy and subclinical deficiency, the amount of vitamin C required for good health and, in particular, the speculative use of high doses of vitamin C t...

Coarctation of the aorta is by no means an uncommon lesion. Two types are generally recognized (1) the infantile, in which there is a diffuse narrowing of the aorta between the origin of the left subclavian artery and the insertion of the ductus arteriosus, and (2) the adult type, in which the area of constriction is very narrow, and is situated at or close to the site of insertion of the ductu...

TO THE EDITOR—We would like to highlight the importance of performing tests to facilitate targeted electrolyte replacement in patients with Ebola virus disease (EVD). Patients with EVD often develop gastrointestinal symptoms including abdominal pain, nausea, and anorexia followed by vomiting and profuse diarrhea [1, 2]. The gastrointestinal losses may be significant, leading to profound hypovol...

A married man aged 53 reported to the venereal diseases clinic in March, 1949, when he was found to have syphilis with an early secondary rash. A penile sore was present, and the Wassermann reaction was strongly positive. Treatment with Stabilarsan and bismuth was begun, and he received a total of 16-2 g. of the former, and 5 7 g. of the latter (a normal course) between March, 1949, and January...

In all of endovascular medicine, the most challenging subset of lesions to treat remains chronic total occlusions (CTOs). Treatment options for CTOs, both in the coronary and peripheral vasculature, continue to be a significant unmet clinical need and opportunity facing interventional cardiology. CTOs usually comprise of a combination of fibrocalcific and thrombotic elements that have been in e...

Oral contraceptives containing only a progestogen have had a chequered career. In 1965 trials in Latin America showed that very small amounts of a progestogen, chlormadinone acetate, when given without any added oestrogen had a strong antifertility effect. Not all progestogens are suitable for use alone. Indeed with norethynodrel, the progestogen most commonly used in the late 1960s, the amount...

Introduction A point:counterpoint series (15,23,24,27,28) sparked much debate among altitude researchers about the existence of different physiological responses between normobaric hypoxia (hypoxia caused by lowering ambient air concentration of oxygen while at sea level air pressure [NH]) and hypobaric hypoxia (hypoxia caused by low ambient air pressure which results in low levels of oxygen ab...