315 Introduction In recent times, there have been two striking developments in the area of insulin therapy. On the therapy front, insulin therapy especially in type 2 diabetes has become a topic frequently reviewed in literature (Marre, 2000; Korytkowski, 2000). These reviews discuss the role of early insulin initiation in the light of the growing burden of type 2 diabetes coupled with the need...

Type 2 diabetes is characterized by progressive beta-cell failure. Indications for exogenous insulin therapy in patients with this condition include acute illness or surgery, pregnancy, glucose toxicity, contraindications to or failure to achieve goals with oral antidiabetic medications, and a need for flexible therapy. Augmentation therapy with basal insulin is useful if some beta-cell functio...

Fewer than 30 % of patients with diabetes who are on insulin therapy achieve target glycated haemoglobin (HbA1C) levels. Automated bolus calculators (ABCs) are now almost universally used for patients on insulin pump therapy to calculate pre-meal insulin doses. Use of ABCs in glucose monitors and smart phone applications have the potential to improve glucose control in a larger population of in...

Objective To examine the efficacy and safety of combination therapy with exenatide plus pioglitazone vs basal/bolus insulin in patients with poorly controlled type 2 diabetes mellitus (T2DM) with very high hemoglobin A1c (HbA1c) (>10%) receiving sulfonylurea plus metformin and with a long duration of disease. Design and Participants Participants (n = 101) in the Qatar Study with very poor gly...

Background: Substantial studies have demonstrated that fasting therapy (FT) can inhibit the inflammatory response and improve insulin resistance (IR); however, underlying mechanisms are still unclear. This study aimed to explore related of intermittent FT for treatment IR.

BACKGROUND AND OBJECTIVES The INSTIGATE study was designed to assess direct health care costs incurred by patients with type 2 diabetes mellitus (T2DM) who start insulin therapy in Spain. It was a multicenter, observational, non-interventional, prospective study. METHODS Direct costs per patient in standard clinical practice were assessed for 6 months before and after the start of insulin the...