Mutations in the erm(41) gene of M.abscessus group organisms are associated with differences in inducible macrolide resistance, with current recommendations being to hold rapidly growing isolates for up to 14 days in order to ensure that resistance which develops more slowly can be detected. This study aimed to determine the ideal incubation time for accurate identification of inducible macroli...

background: during the initial phase of an infection, there is an upregulation of inducible nitric oxide synthase in the macrophages for the production of nitric oxide. this is followed by the recruitment of polymorphonuclear leukocytes (neutrophils) which release arginase. arginase competes with inducible nitric oxide synthase for a common substrate l-arginine. objective: to investigate whethe...

Metazoan diversification occurred during a time when atmospheric oxygen levels fluctuated between 15 and 30%. The hypoxia-inducible factor (HIF) is a primary regulator of the adaptive transcriptional response to hypoxia. Although the HIF pathway is highly conserved, its complexity increased during periods when atmospheric oxygen concentrations were increasing. Thus atmospheric oxygen levels may...

Hypoxia-inducible factor (HIF) is a sequence-specific DNA-binding protein that can promote or repress the transcription of a broad range of genes that are involved in maintaining biological homeostasis. HIF is mostly non-functional in oxygenated cells but becomes active under specific conditions, including lowoxygen (hypoxic) stress. HIF is a heterodimeric complex that is composed of an oxygen-...

Introduction: In the present study, the effect of an inducible NO synthase (iNOS) inhibitor, aminoguanidine (AG) on lipopolysaccharide (LPS)-induced memory impairment and oxidative stress and inflammation parameters was evaluated. Materials and Methods: The rats were divided into 5 groups and treated: 1) Control (Saline), 2) LPS (1 mg/kg), 3-5) AG 50, 100 and 150mg/kg 30 min before LPS injectio...

Hypoxia-inducible factor 1alpha (HIF-1alpha) is a transcriptional factor that regulates genes involved in response to hypoxia and promotes neoangiogenesis, which are considered essential for tumor growth and progression. Using immunohistochemistry, we investigated the influence of HIF-1alpha expression on prognosis in 91 patients with cervical cancer stage pT1b. In univariate and multivariate a...

Brugada syndrome is a rare inherited channelopathy associated with an increased risk of ventricular tachycardia and fibrillation, leading to syncope sudden cardiac death. We present case report young patient inducible type 1 pattern on electrocardiogram (ECG), accompanied by comprehensive literature review. The 19-year-old presented dizziness exhibited 2 admission ECG, which converted following...

Abstract Background COVID-19 affected the epidemiology of many respiratory pathogens including GAS. Assessing genetic heterogeneity (emm type, antimicrobial resistance, virulence factors) can inform treatment recommendations and targets for potential GAS vaccines. We assessed clinical antibiotic susceptibility performed whole genome sequencing (WGS) among pediatric pharyngeal isolates from 2020...