a normal life span. It has recently been shown that CCHS confers risk for adverse neurocognitive outcome [3]. Visuoperceptual reasoning and clerical/ visuographic speed appear particularly vulnerable. In this issue of IMAJ, Cohen-Cymberknoh and colleagues [4] present an interesting and unusual case of a 12 year old girl with late-onset CCHS that was suspected and diagnosed only after she failed...

(Chest 1990; 98:474-80) C hronic alveolar hypoventilation, defined as a sustamed increase in PCO2 exceeding 45 mm Hg, is a condition commonly encountered by the chest physician. Most cases are related to chronic airway obstruction, but a substantial minority of cases have other contributing factors such as ventilatory control defects, respiratory muscle weakness, or a combination of factors. 1....

BACKGROUND As part of our overall interest in the mechanisms and treatment related to the development of the lethal triad of hypothermia, acidosis, and coagulopathy seen in trauma patients, the purpose of this study was to determine whether acidosis, inducible either by HCl infusion or hemorrhage/hypoventilation, leads to coagulopathy, and if correction of the acidosis will alleviate this coagu...

Disturbances in the relationship of ventilation and perfusion may result in hypoxemia, a deficiency of oxygen in the blood. The four major causes of hypoxemia are hypoventilation, alveolar-capillary diffusion impairment, shunt, and ventilation perfusion mismatch.1 In this article factors which determine ventilation and gas exchange will be identified and abnormalities leading to hypoxemia will ...