نتایج جستجو برای: hypertonicity

تعداد نتایج: 682  

2005
Cheng Zhou Hai-Qing Chen Rustin Reeves Neeraj Agarwal

Purpose. To examine the effect of hypertonicity on the induction of the Na-myo-inositol (Na-MI) cotransporter(s) in cultured bovine lens epithelial cells (BLECs). Methods. Na-MI cotransporter 626-bp reverse transcription-polymerase chain reaction product amplified from lens cell RNA and aldose reductase (AR) cDNA probes were used to measure respective mRNA content by Northern blot analysis. Res...

Journal: :The Journal of clinical investigation 1992
D W Good

UNLABELLED Previously we demonstrated that arginine vasopressin (AVP) directly inhibits bicarbonate absorption (JHCO3, pmol/min per mm) in the medullary thick ascending limb (MTAL) of the rat. To determine whether changes in osmolality also may affect bicarbonate absorption, MTAL were studied in vitro with 25 mM HCO3- solutions. Control osmolality was 290 mosmol/kg H2O. In the absence of AVP, i...

Journal: :General physiology and biophysics 2004
B Rouzaire-Dubois J M Dubois

While there is increasing evidence that Ca2+ plays an important role in regulating cell proliferation, the precise mechanisms have not been clearly elucidated so far. In order to gain insight into how Ca2+ controls cell division, the rate of proliferation, cell volume, viability and attachment to the culture support were measured in NG108-15 neuroblastoma cells in the presence of various extrac...

Journal: :Journal of neurochemistry 2008
Imola Wilhelm Péter Nagyoszi Attila E Farkas Pierre-Olivier Couraud Ignacio A Romero Babette Weksler Csilla Fazakas Ngo Thi Khue Dung Sándor Bottka Hannelore Bauer Hans-Christian Bauer István A Krizbai

Because of the relative impermeability of the blood-brain barrier (BBB), many drugs are unable to reach the CNS in therapeutically relevant concentration. One method to deliver drugs to the CNS is the osmotic opening of the BBB using mannitol. Hyperosmotic mannitol induces a strong phosphorylation on tyrosine residues in a broad spectrum of proteins in cerebral endothelial cells, the principal ...

1998
DAVID W. GOOD

absorption in thick ascending limb: modifying effects of vasopressin. Am. J. Physiol. 274 (Cell Physiol. 43): C931– C939, 1998.—Growth factors stimulate Na1/H1 exchange activity in many cell types but their effects on acid secretion via this mechanism in renal tubules are poorly understood. We examined the regulation of HCO3 2 absorption by nerve growth factor (NGF) in the rat medullary thick a...

Journal: :Journal of pediatric surgery 2000
R K Minkes J C Langer

BACKGROUND Internal anal sphincter hypertonicity with nonrelaxation can cause persistent constipation and obstructive symptoms in children after surgery for Hirschsprung's disease. Intractable symptoms traditionally have been treated with anal myectomy, which may be ineffective or complicated by long-term incontinence. The authors evaluated prospectively the use of intrasphincteric botulinum to...

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