COVID-19 disease has emerged worldwide, and recently vaccination become the most powerful weapon to overcome this pandemic. Indonesia begun their program since January 13, 2021, with President Joko Widodo as first participant in program. However, cumulative cases is still increasing, 939,948 confirmed per 21, 8,000 – 14,000 single day within last week report. This issue will lead higher morbidi...

Dahlback in 1993 and Bertina in 1994 made the landmark discovery that resistance to activated protein C due to a point mutation in the factor V gene (G1691A in exon 10, leading to Arg506Gln) is associated with a 6to 8-fold increased risk of venous thrombosis.1,2 The importance of these findings, which have since been confirmed and cited more than 2000 times in the medical literature, is due to ...

The purpose of this study was to evaluate whether or not, using sensitive analytical methods for the measurement of coagulation and fibrinolysis enzyme activity, there was a hypercoagulable state in patients with melanoma, and whether differences existed between those with or without metastases. Seventy-one patients were studied, 45 with localized tumors (stages Ia and Ib) and 26 with metastase...

Non-valvar atrial fibrillation confers a substantial risk for stroke and thromboembolism which is estimated to be between 4-5% and 12% per year depending on associated risk factors.'2 Recent studies have established the value of warfarin as thromboprophylaxis in atrial fibrillation; however, this treatment carries with it the inconvenience of regular monitoring of anticoagulation intensity and ...

PURPOSE The purpose of this study was to investigate the serum hypercoagulability state and common viral and protozoan infections in Coats' disease versus a normal control group. MATERIALS AND METHODS In this comparative case series, 22 consecutive patients with Coats' disease and 19 non-Coats' patients undergoing lensectomy for congenital, traumatic, or senile cataract between January 2011 a...

Hemoglobin SC disease is a very prevalent hemoglobinopathy; however, very little is known about this condition specifically. There appears to be an increased risk of thromboembolic events in hemoglobin SC disease, but studies evaluating the hemostatic alterations are lacking. We describe the findings of a cross-sectional observational study evaluating coagulation activation markers in adult pat...

A 39 year old man with Marfan syndrome presented with multiple pulmonary emboli and renal, hepatic, and splenic infarcts of unknown aetiology. The combination of thromboemboli and physical features initially suggested homocystinuria; however, laboratory examination showed no evidence for this disorder. Laboratory evaluation identified no coagulation abnormalities. This patient represents the un...