UNLABELLED Breast and endometrial cancers are the most common invasive malignancies in women, with more than 217,000 new diagnoses per year in the United States. These cancers are often classified into 2 subtypes based on the expression of the classical estrogen receptor. In this study, we describe a new structural class of neutral tridentate 99mTc(I)-estradiol-pyridin-2-yl hydrazine derivative...

Objective(s): The significant contribution of nanoparticles to cancer treatment has attracted therapeutic attention. The present study aimed to evaluate the synergistic effects of 5-fluorouracil (5-FU) and zinc oxide nanoparticles (ZnO NPs) as multimodal drug delivery on human breast cancer MCF-7 cells.Materials and Methods: In this in-vitro study, the impact of 5-FU and ZnO NPs in the sin...

Co-delivery approach has been recommended to reduce the amount of each drug and to achieve the synergistic effect for cancer treatment. CUR and SF have antitumor effects, but their application is limited because of their low water solubility and poor oral bioavailability. To improve the bioavailability and solubility of SF and CUR, we performed an innovative co-delivery of SF and CUR with magne...

A series of novel enantiopure isoxazolidine derivatives were synthesized and evaluated for their anticancer activities against three human cancer cell lines such as breast carcinoma (MCF-7), lung adenocarcinoma (A-549), ovarian (SKOV3) by employing MTT assay. The compounds characterized NMR elemental analysis. Results revealed that all the displayed significant inhibition towards tested lines. ...

Landomycin E (LE) was recently isolated from Streptomyces globisporus strain 1912 and its chemical structure was studied. However, its biological activity is still poorly understood. We performed in vitro investigation of antitumor activity of this new member of the angucyclin family of antibiotics. Dose-dependent effect of LE on growth and survival of different tumor cell lines was studied in ...

Background and Aims: Bongardia chrysogonum (L.) Spach (Berberidaceae), an ancient medicinal plant in Eastern Mediterranean countries, is traditionally used for the treatment of epilepsy, hemorrhoids, urinary system infections gastrointestinal disorders. This study was designed to evaluate potential neuroprotective anticancer effects different parts from B. chrysogonum. Material Methods: Leaf,...

In vitro studies on cancer cell lines still constitutes a major part of cancer research. It is very important that the researchers consider the importance of basic conditions of working with different cell lines. To the best of authors knowledge, this study is the first one to report the effect of seeding density on the growth curve of three human cancer cell lines. These cell lines include hum...