BACKGROUND The prevalence of metabolic diseases rises rapidly with an ageing population. Recent studies suggest the potential involvement of environmental chemicals in insulin resistance (IR) that plays a core role in the development of metabolic diseases. Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous components of outdoor and indoor air pollution. The influence of PAHs on IR may diffe...

OBJECTIVE Insulin resistance (IR) may not only increase stroke risk, but could also contribute to aggravate stroke prognosis. Mainly through a derangement in endogenous fibrinolysis, IR could affect the response to intravenous thrombolysis, currently the only therapy proved to be efficacious for acute ischemic stroke. We hypothesized that high IR is associated with more persistent arterial occl...

OBJECTIVE The goal of this study was to investigate whether the effects of common genetic variants associated with fasting glucose in adults are detectable in healthy children. RESEARCH DESIGN AND METHODS Single nucleotide polymorphisms in MTNR1B (rs10830963), G6PC2 (rs560887), and GCK (rs4607517) were genotyped in 2,025 healthy European children aged 9-11 and 14-16 years. Associations with f...

This study was designed to investigate the relation of insulin resistance, blood glucose and inflammatory cytokines with cardiovascular events in diabetic patients complicated with coronary heart disease (CHD). A total of 120 patients with diabetes mellitus type 2 (T2DM) complicated with CHD admitted to Jinan Central Hospital from January 2015 to March 2016 were enrolled in this study. There we...

Background: Polycystic ovarian syndrome is one of the most common metabolic and endocrine disorders among women, whereas vitamin D a steroid with hormone like activity also considered as missing link between insulin resistance PCOS due to its underlying mechanism action in reducing thereby altering pathogenesis behind symptoms.Methods: A prospective cohort comparative observational study was ca...

background non-alcoholic fatty liver disease (nafld) is considered as the hepatic manifestation of insulin resistance (ir) syndrome. the effect of insulin sensitizers on liver function tests and metabolic indices in nafld patients is a matter of debate. objectives the aim of study was to compare the effects of two different insulin sensitizers, pioglitazone, and metformin, on liver function tes...

Results For the IR assessed by the clamp, the HOMA-AD demonstrated a stronger coefficient of correlation (r=0.64) compared with the HOMA-IR (r=-0.56); p<0.0001. In the ROC analysis, compared with the HOMA-IR, the HOMA-AD showed higher values of the AUC for the identification of IR based on the clamp test (AUC: 0.844 vs. AUC: 0.804) and on the metabolic syndrome (AUC: 0.703 vs. AUC: 0.689), resp...

Background: Insulin resistance is a major cause for developing type 2 diabetes. However, simultaneously pancreatic beta-cell dysfunction must coexist in clinical occurrence of diabetes (T2D). Hence, knowledge regarding residual function and degree insulin required while treating diabetic patients. Aims Objectives: The present study was done to estimate (homeostatic model assessment - HOMA-IR) f...

OBJECTIVE To characterize and compare the beta-cell function and insulin resistance among Peruvian adolescents with type 2 diabetes (T2D) and their non-diabetic, overweight and lean peers. METHODS Cross-sectional study of 54 adolescents aged 10-19 years, distributed in three sex- and age-matched groups (n = 18): (i) adolescents with T2D; (ii) overweight adolescents without T2D; and (iii) lean...