نتایج جستجو برای: hippocampal ca1

تعداد نتایج: 46398  

Journal: :Sheng li xue bao : [Acta physiologica Sinica] 2006
Li Chen Ma-Li Jiang Tai-Zhen Han

Previous reports suggested that a low-frequency stimulus (LFS) of 1~2 Hz (600~900 pulses) induced a homosynaptic long-term depression (LTD) of synaptic efficacy in the hippocampal CA1 area of young rats (< 4-week old). However, these stimulation protocols often failed to induce LTD in the adult CA1 hippocampus. In the present study, we examined the effects of two novel tetanus patterns on LTD i...

Journal: :Experimental Neurology 2016
Omar C. Logue Nathan P. Cramer Xiufen Xu Daniel P. Perl Zygmunt Galdzicki

Traumatic brain injury (TBI) is the leading cause of death for persons under the age of 45. Military service members who have served on multiple combat deployments and contact-sport athletes are at particular risk of sustaining repetitive TBI (rTBI). Cognitive and behavioral deficits resulting from rTBI are well documented. Optimal associative LTP, occurring in the CA1 hippocampal Schaffer coll...

Journal: :basic and clinical neuroscience 0
gholamreza hassanzadeh mitra barzroodi pour mohammad bayat miriam javadi

abstractintroduction: previous investigations have shown that protein malnutrition can alters the structure and function of some areas of hippocampal formation. we investigated the effect of protein malnutrition on amygdaloid projections to the ca1 hippocampal area. in this study we investigated level and pattern of distribution of efferent projections from amygdala to hippocampus in the rat by...

2015
Fang Li Chao-Qun Yan Li-Ting Lin Hui Li Xiang-Hong Zeng Yi Liu Si-Qi Du Wen Zhu Cun-Zhi Liu

BACKGROUND Decreased cognition is recognized as one of the most severe and consistent behavioral impairments in dementia. Experimental studies have reported that acupuncture may improve cognitive deficits, relieve vascular dementia (VD) symptoms, and increase cerebral perfusion and electrical activity. METHODS Multi-infarction dementia was modeled in rats with 3% microemboli saline suspension...

Journal: :Journal of neurochemistry 2005
Kenneth T Kishida Maryland Pao Steven M Holland Eric Klann

Previous studies have shown that N-methyl-D-aspartate (NMDA) receptor activation results in production of reactive oxygen species (ROS) and activation of extracellular signal-regulated kinase (ERK) in hippocampal area CA1. In addition, application of ROS to hippocampal slices has been shown to result in activation of ERK in area CA1. To determine whether these events were linked causally, we in...

Journal: :Tropical Journal of Pharmaceutical Research 2021

Purpose: To study the protective effect of oxytocin on hypoxic-ischemic brain neuron injury in neonatal rats, and mechanism action involved.Methods: Hippocampal slices from SD rats were cultured oxygen/glucose-deprived (OGD) solution, leading to establishment model hippocampal vitro. The assigned 3 groups: control (ACSF solution), (OGD solution + 1 μM oxytocin). vertebral neurons CA1 region HIB...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2011
Thorsten Bartsch Juliane Döhring Axel Rohr Olav Jansen Günther Deuschl

Autobiographical memories in our lives are critically dependent on temporal lobe structures. However, the contribution of CA1 neurons in the human hippocampus to the retrieval of episodic autobiographical memory remains elusive. In patients with a rare acute transient global amnesia, highly focal lesions confined to the CA1 field of the hippocampus can be detected on MRI. We studied the effect ...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2004
Iman H Brivanlou Jami L M Dantzker Charles F Stevens Edward M Callaway

The hippocampus is a cortical region thought to play an important role in learning and memory. Most of our knowledge about the detailed organization of hippocampal circuitry responsible for these functions is derived from anatomical studies. These studies present an incomplete picture, however, because the functional character and importance of connections are often not revealed by anatomy. Her...

2011
Kuo-Ping Huang Freesia L. Huang

Calmodulin (CaM) and neurogranin (Ng) are two abundant neuronal proteins whose interactions are implicated in the regulation of synaptic responses and plasticity. We employed the "low-calcium" model of epilepsy in hippocampal slices to investigate the mobilization of these two proteins in CA1 pyramidal neurons. Perfusion of mouse hippocampal slices with Ca(2+)-free artificial CSF (ACSF) caused ...

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