Thermal Process Safety Based on Reaction Kinetics and Reactor Dynamics Charles Guinand, Michal Dabros, Bertrand Roduit, Thierry Meyer, Francis Stoessel HES-SO Haute école spécialisée de Suisse occidentale, Haute école d’ingénierie et d’architecture Fribourg, Institut ChemTech, 1705 Fribourg, Switzerland Ecole Polytechnique Fédérale de Lausanne, 1015 Lausanne, Switzerland AKTS AG, http://www.akt...

BACKGROUND This meta-analysis was to determine the association of the cumulative dose of 130/0.4 or 0.42 (hydroxyethyl starch [HES] 130/0.4*) or delta daily fluid balance (i.e., daily fluid balance in HES group over or below control group) with the heterogeneity of risk ratio (RR) for mortality in randomized control trials (RCTs). METHODS Three databases (PubMed, EMBASE, Cochrane) were search...

BACKGROUND Previous studies reported a higher mortality risk and a greater need for renal replacement therapy in patients administered hydroxyethyl starch (HES) rather than other fluid resuscitation preparations. In this study, we investigated the association between 6% HES 70/0.5 use and postoperative acute kidney injury (AKI) in gastroenterological surgery patients. METHODS We conducted ret...

Platelets were cryopreserved in four different cryoprotectives-two intracellular (dimethylsulphoxide, glycerol) and two extracellular (hydroxyethyl starch, dextran). The platelets were evaluated according to their yields, hypotonic shock response, and serotonin uptake, which are useful parameters for establishing optimum storage conditions. Hydroxyethyl starch and dextran were found to be poor ...

OBJECTIVE The purpose of this study was to investigate the effects of acute hypervolemic fluid infusion (AHFI) of 6% hydroxyethyl starch (HES) 130/0.4 or 4% succinylated gelatin (GEL) on hemostasis and the possible mechanisms. METHODS Thirty-six gastric cancer patients were randomized to receive AHFI of either HES, GEL or lactated Ringer's (RL) solution at the rate of 30 mL x kg(-1) x h( -1) ...

This review summarises the new insights into the physiology of perioperative fluid therapy and analyses recent studies of the safety of the use of HES solutions in the fluid management of critically ill patients. This analysis reveals a number of methodological issues in the three major studies that have initiated the recommendation of the European Medicine Agency to ban hydroxyethyl starches f...

BACKGROUND General population health examination surveys (HESs) provide a reliable source of information to monitor the health of populations. A number of countries across Europe are currently planning their first HES, or the first after a significant gap, and some of these intend offering appointments only during office hours and/or weekdays, raising concerns about representativeness of survey...

117 RefeRences 1. Ma PL, Peng XX, Du B, Hu XL, Gong YC, Wang Y, et al. Sources of heterogeneity in trials reporting hydroxyethyl starch 130/0.4 or 0.42 associated excess mortality in septic patients: A systematic review and meta‐regression. Chin Med J 2015;128:2374‐82. doi: 10.4103/0366‐ 6999.163387. 2. Zhu GC, Quan ZY, Shao YS, Zhao JG, Zhang YT. The study of hypertonic saline and hydroxyethyl...

Antifreeze protein (AFP) types, I, II and III were tested for their ability to protect red blood cells from lysis during warming, after cryopreservation in hydroxyethyl starch. All three types reduced hemolysis to 25% of control values at similar micromolar concentrations but enhanced lysis as the AFP concentration approached millimolar levels. Site-directed mutants of type III AFP with differe...